ArticleThe American journal of tropical medicine and hygiene2011
Dexamethasone effects in the Strongyloides venezuelensis infection in a murine model.
Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Circulating Leukocytes and Antibody Isotype Reactivity in Rats Experimentally Infected with Different Burdens ofTropical medicine and infectious disease · 2026Article
- Strongyloides hyperinfection syndrome precipitated by immunosuppressive therapy for rheumatoid arthritis and COVID-19 pneumonia.Tropical diseases, travel medicine and vaccines · 2023Article
- Route of dexamethasone administration influences parasite burden inJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Magic bullets, magic shields, and antimicrobials in between.Pharmaceutical science advances · 2023Review
- Exposure to dexamethasone modifies transcriptomic responses of free-living stages of Strongyloides stercoralis.PloS one · 2021Article
- Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19.The American journal of tropical medicine and hygiene · 2020Article
- Strongyloidiasis: A Neglected Tropical Disease.Infectious disease clinics of North America · 2019Review
- [Gastrointestinal tract diseases induced by medications].Der Pathologe · 2018Review
- Imported Disease Screening Prior to Chemotherapy and Bone Marrow Transplantation for Oncohematological Malignancies.The American journal of tropical medicine and hygiene · 2016Article
- Strongyloides stercoralis infection in marmosets: replication of complicated and uncomplicated human disease and parasite biology.Parasites & vectors · 2014Article
- Tamoxifen treatment in hamsters induces protection during taeniosis by Taenia solium.BioMed research international · 2013Article
- Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model.Immunologic research · 2011Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the immunomodulatory effects of glucocorticoids on the immune response to Strongyloides venezuelensis in mice. Balb/c mice were infected with S. venezuelensis and treated with Dexamethasone (Dexa) or vehicle. Dexa treatment increased circulating blood neutrophil numbers and inhibited eosinophil and mononuclear cell accumulation in the blood, bronchoalveolar, and peritoneal fluid compared with control animals. Moreover, Dexa decreased tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-3 (IL-3), IL-4, IL-5, IL-10, and IL-12 production in the lungs and circulating immunoglobulin G1 (IgG1), IgG2a, and IgE antibody levels while increasing the overall parasite burden in the feces and intestine. Dexa treatment enhanced the fertility of female nematodes relative to untreated and infected mice. In summary, the alterations in the immune response induced by Dexa resulted in a blunted, aberrant immune response associated with increased parasite burden. This phenomenon is similar to that observed in S. stercoralis-infected humans who are taking immunosuppressive or antiinflammatory drugs, including corticosteroids.
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