ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Assessing the Causal Relationships Between Lipid Species and Stroke by Using Mendelian Randomization.Molecular neurobiology · 2025Article
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- Endogenous Neural Stem Cell-induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives.Translational stroke research · 2023Review
- Regulatory effects and potential therapeutic implications of alarin in depression, and arguments on its receptor.Frontiers in psychiatry · 2022Review
- The evolving roles of alarin in physiological and disease conditions, and its future potential clinical implications.Frontiers in endocrinology · 2022Review
- Promoter DNA hypermethylation - Implications for Alzheimer's disease.Neuroscience letters · 2019Review
- Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility.Science signaling · 2019Article
- Kinase Inhibitors with Antiepileptic Properties Identified with a Novel in Vitro Screening Platform.International journal of molecular sciences · 2019Article
- Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons.International journal of molecular sciences · 2018Review
- Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata.Scientific reports · 2017Article
- Article
- Defective phosphoinositide metabolism in autism.Journal of neuroscience research · 2017Review
- Neurogenesis in Stroke Recovery.Translational stroke research · 2017Review
- α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction.Biological chemistry · 2016Review
- Developmental Dynamics of Rett Syndrome.Neural plasticity · 2016Review
- Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.Molecular autism · 2016Article
- Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Cell reports · 2015Article
- Norepinephrine Protects against Amyloid-β Toxicity via TrkB.Journal of Alzheimer's disease : JAD · 2015Article
- Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Phosphoinositide 3-kinase enhancer (PIKE) binds and enhances phosphatidylinositol 3-kinase (PI3K)/Akt activities. However, its physiological functions in brain have never been explored. Here we show that PIKE is important in regulating the neuronal survival and development of neocortex. During development, enhanced apoptosis is observed in the ventricular zone of PIKE knock-out (PIKE(-/-)) cortex. Moreover, PIKE(-/-) neurons show reduced dendritic complexity, dendritic branch length, and soma size. These defects are due to the reduced PI3K/Akt activities in PIKE(-/-) neurons, as the impaired dendritic arborization can be rescued when PI3K/Akt cascade is augmented in vitro or in PIKE(-/-)PTEN(-/-) double-knock-out mice. Interestingly, PIKE(-/-) mice display behavioral abnormality in locomotion and spatial navigation. Because of the diminished PI3K/Akt activities, PIKE(-/-) neurons are more vulnerable to glutamate- or stroke-induced neuronal cell death. Together, our data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.