ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Synapse specific alterations of autophagy are a hallmark of Danon disease.bioRxiv : the preprint server for biology · 2026Article
- Prolonged visual experience accelerates developmental synaptic downscaling via epigenetic regulation and Rab5c mediated AMPA receptor trafficking.Communications biology · 2026Article
- Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026Review
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tetrode Recording in theCold Spring Harbor protocols · 2021Article
- Experience-dependent development of visual sensitivity in larval zebrafish.Scientific reports · 2019Article
- The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs.Cell reports · 2017Article
- Article
- Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits.Neural development · 2016Article
- Article
- An Evolutionarily Conserved Mechanism for Activity-Dependent Visual Circuit Development.Frontiers in neural circuits · 2016Review
- HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the DevelopingFrontiers in cellular neuroscience · 2016Article
- Emergence of Selectivity to Looming Stimuli in a Spiking Network Model of the Optic Tectum.Frontiers in neural circuits · 2016Article
- Article
- Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.Disease models & mechanisms · 2013Review
- Global hyper-synchronous spontaneous activity in the developing optic tectum.Scientific reports · 2013Article
- A competition-based mechanism mediates developmental refinement of tectal neuron receptive fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The functional properties of neural circuits become increasingly robust over development. This allows circuits to optimize their output in response to a variety of input. However, it is not clear whether this optimization is a function of hardwired circuit elements, or whether it requires neural experience to develop. We performed rapid in vivo imaging of calcium signals from bulk-labeled neurons in the Xenopus laevis optic tectum to resolve the rapid spatiotemporal response properties of populations of developing tectal neurons in response to visual stimuli. We found that during a critical time in tectal development, network activity becomes increasingly robust, more correlated, and more synchronous. These developmental changes require normal visual input during development and are disrupted by NMDAR blockade. Our data show that visual activity and NMDAR activation are critical for the maturation of tectal network dynamics during visual system development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.