ArticleThe Journal of clinical endocrinology and metabolism2011
Cardiac dimensions are largely determined by dietary salt in patients with primary aldosteronism: results of a case-control study.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Pooled it
- Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism.TheScientificWorldJournal · 2013Trial
- Comparative analysis of cardiac dysfunction in non-functioning adrenal adenomas, primary aldosteronism, and essential hypertension.Journal of endocrinological investigation · 2025Article
- Association Between Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross-Sectional Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Aldosterone-induced salt appetite requires HSD2 neurons.JCI insight · 2024Article
- Biomarkers to Guide Medical Therapy in Primary Aldosteronism.Endocrine reviews · 2024Review
- Aldosterone Effect on Cardiac Structure and Function.Current cardiology reviews · 2024Review
- Serum aldosterone effect on left ventricular structure and diastolic function in essential hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- The spectrum of plasma renin activity and hypertension diseases: Utility, outlook, and suggestions.Journal of clinical laboratory analysis · 2022Review
- Strain Imaging for the Early Detection of Cardiac Remodeling and Dysfunction in Primary Aldosteronism.Diagnostics (Basel, Switzerland) · 2022Review
- Serum aldosterone and urine electrolytes dynamics in response to DASH diet intervention - An inpatient mechanistic study.Journal of clinical and translational science · 2022Article
- Review
- Left ventricular remodeling and dysfunction in primary aldosteronism.Journal of human hypertension · 2021Review
- Sodium Intake and Target Organ Damage in Hypertension-An Update about the Role of a Real Villain.International journal of environmental research and public health · 2020Review
- Serum-soluble (pro)renin receptor concentration as a biomarker for organ damage in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.Nature communications · 2019Article
- Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.Free radical biology & medicine · 2019Article
- Increased myocardial sodium signal intensity in Conn's syndrome detected by 23Na magnetic resonance imaging.European heart journal. Cardiovascular Imaging · 2019Article
- The relationship among cardiac structure, dietary salt and aldosterone in patients with primary aldosteronism.Oncotarget · 2017Article
- Endocrine Tumors Causing Arterial Hypertension: Pathophysiological Mechanisms and Clinical Implications.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAnimal studies have demonstrated that dietary sodium intake is a major influence in the pathogenesis of aldosterone-induced effects in the heart such as left ventricular (LV) hypertrophy and fibrosis. LV hypertrophy is an important predictor for cardiovascular morbidity and mortality.
objectiveWe aimed to investigate the relationships between aldosterone and dietary salt and LV dimensions in patients with primary aldosteronism (PA). DESIGN AND
participantsThis case-control study included 21 patients with confirmed PA and 21 control patients with essential hypertension matched for age, gender, duration of hypertension, and 24-h systolic and diastolic blood pressure.
main outcome measuresPatients were evaluated by echocardiography and 24-h urinary sodium (UNa) excretion while consuming their usual diets.
resultsPatients with PA had significantly greater mean LV end-diastolic diameter, interventricular septum and posterior wall thicknesses, LV mass (LVM) and LV mass index, and end systolic and diastolic volumes than control patients. UNa significantly positively correlated with interventricular septum, posterior wall thicknesses, and LVM in the patients with PA but not in control patients. In a multivariate analysis, UNa was an independent predictor for LV wall thickness and LV mass among the patients with PA but not in patients with essential hypertension.
conclusionsThese findings emphasize the importance of dietary sodium in determining the degree of cardiac damage in those patients with PA, and we suggest that aldosterone excess may play a permissive role. In patients with PA, because a high-salt diet is associated with greater LVM, dietary salt restriction might reduce cardiovascular risk.
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