ReviewJournal of the Royal Society, Interface2011
Probing mechanical principles of focal contacts in cell-matrix adhesion with a coupled stochastic-elastic modelling framework.
Review in Journal of the Royal Society, Interface, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery.Mechanobiology in medicine · 2024Review
- A multi-scale clutch model for adhesion complex mechanics.PLoS computational biology · 2023Article
- Elasticity-associated rebinding rate of molecular bonds between soft elastic media.Biophysical journal · 2022Article
- Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking.Journal of the Royal Society, Interface · 2022Article
- A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Cellular nanoscale stiffness patterns governed by intracellular forces.Nature materials · 2019Article
- An electro-osmotic microfluidic system to characterize cancer cell migration under confinement.Journal of the Royal Society, Interface · 2019Article
- Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions.Biophysical journal · 2018Article
- Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effects of ligand distribution on receptor-diffusion-mediated cellular uptake of nanoparticles.Royal Society open science · 2017Article
- The Effect of Thermal Fluctuation on the Receptor-Mediated Adhesion of a Cell Membrane to an Elastic Substrate.Membranes · 2017Article
- A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesion.Royal Society open science · 2016Article
- Binding equilibrium and kinetics of membrane-anchored receptors and ligands in cell adhesion: Insights from computational model systems and theory.Cell adhesion & migration · 2016Review
- Expression of VEGF in neonatal urinary obstruction: does expression of VEGF predict hydronephrosis?Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Investigating biomechanical noise in neuroblastoma cells using the quartz crystal microbalance.Journal of the Royal Society, Interface · 2015Article
- Probing time-dependent mechanical behaviors of catch bonds based on two-state models.Scientific reports · 2015Article
- Non-uniform breaking of molecular bonds, peripheral morphology and releasable adhesion by elastic anisotropy in bio-adhesive contacts.Journal of the Royal Society, Interface · 2015Article
- Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model.BMC systems biology · 2014Article
- USNCTAM perspectives on mechanics in medicine.Journal of the Royal Society, Interface · 2014Article
- Probing cellular mechanoadaptation using cell-substrate de-adhesion dynamics: experiments and model.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-matrix adhesion depends on the collective behaviours of clusters of receptor-ligand bonds called focal contacts between cell and extracellular matrix. While the behaviour of a single molecular bond is governed by statistical mechanics at the molecular scale, continuum mechanics should be valid at a larger scale. This paper presents an overview of a series of recent theoretical studies aimed at probing the basic mechanical principles of focal contacts in cell-matrix adhesion via stochastic-elastic models in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial traction-separation are unified in a single modelling framework. The intention here is to illustrate these principles using simple analytical and numerical models. The aim of the discussions is to provide possible clues to the following questions: why does the size of focal adhesions (FAs) fall into a narrow range around the micrometre scale? How can cells sense and respond to substrates of varied stiffness via FAs? How do the magnitude and orientation of mechanical forces affect the binding dynamics of FAs? The effects of cluster size, cell-matrix elastic modulus, loading direction and cytoskeletal pretension on the lifetime of FA clusters have been investigated by theoretical arguments as well as Monte Carlo numerical simulations, with results showing that intermediate adhesion size, stiff substrate, cytoskeleton stiffening, low-angle pulling and moderate cytoskeletal pretension are factors that contribute to stable FAs. From a mechanistic point of view, these results provide possible explanations for a wide range of experimental observations and suggest multiple mechanisms by which cells can actively control adhesion and de-adhesion via cytoskeletal contractile machinery in response to mechanical properties of their surroundings.
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