ArticleBiomaterials2011
Magnetically-enabled and MR-monitored selective brain tumor protein delivery in rats via magnetic nanocarriers.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Strategies for Improved Intra-arterial Treatments Targeting Brain Tumors: a Systematic Review.Frontiers in oncology · 2020Pooled it
- Review
- Functional Nanoparticles for Enhanced Cancer Therapy.Pharmaceutics · 2022Review
- Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers.Pharmaceutics · 2021Review
- Magnetically Directed Enzyme/Prodrug Prostate Cancer Therapy Based on β-Glucosidase/Amygdalin.International journal of nanomedicine · 2020Article
- Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy.Frontiers in oncology · 2019Article
- Protein delivery into cells using inorganic nanoparticle-protein supramolecular assemblies.Chemical Society reviews · 2018Review
- Circulating Magnetic Microbubbles for Localized Real-Time Control of Drug Delivery by Ultrasonography-Guided Magnetic Targeting and Ultrasound.Theranostics · 2018Article
- Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- Magnetic targeting of novel heparinized iron oxide nanoparticles evaluated in a 9L-glioma mouse model.Pharmaceutical research · 2014Article
- Enhanced and selective delivery of enzyme therapy to 9L-glioma tumor via magnetic targeting of PEG-modified, β-glucosidase-conjugated iron oxide nanoparticles.International journal of nanomedicine · 2014Article
- Long-circulating heparin-functionalized magnetic nanoparticles for potential application as a protein drug delivery platform.Molecular pharmaceutics · 2013Article
- Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies.Molecular pharmaceutics · 2013Article
- Magnetic nanoparticles for tumor imaging and therapy: a so-called theranostic system.Pharmaceutical research · 2013Review
- Magnetic tumor targeting of β-glucosidase immobilized iron oxide nanoparticles.Nanotechnology · 2013Article
- Design and Application of Magnetic-based Theranostic Nanoparticle Systems.Recent patents on biomedical engineering · 2013Article
- Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics.Expert opinion on drug delivery · 2013Review
- Nanotheranostics--a review of recent publications.International journal of nanomedicine · 2012Review
- A combined theoretical and in vitro modeling approach for predicting the magnetic capture and retention of magnetic nanoparticles in vivo.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The delivery of bioactive proteins to tumors is associated with many difficulties that have impeded clinical translation of these promising therapeutics. Herein we present an approach, including (1) use of magnetically-responsive and MRI-visible nanoparticles as drug carriers, (2) topography-optimized intra-arterial magnetic targeting, (3) MRI-guided subject alignment within the magnetic field, and (4) surface modification of the protein drug with membrane-permeable polyethyleneimine (PEI), to prevail over the obstacles in protein delivery. Applying these methodologies, we demonstrated the delivery of a significant quantity of β-galactosidase selectively into brain tumors of glioma-bearing rats, while limiting the exposure of normal brain regions. Clinical viability of the technologies utilized, and the ability to deliver proteins at high nanomolar-range tumor concentrations, sufficient to completely eradicate a tumor lesion with existing picomolar-potency protein toxins, renders the prospect of enabling protein-based cancer therapy extremely promising.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.