ArticleGenes, brain, and behavior2011
Environmental stress alters genetic regulation of novelty seeking in vervet monkeys.
Article in Genes, brain, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- Epigenetic clock and methylation studies in vervet monkeys.GeroScience · 2022Article
- Inheritance of hormonal stress response and temperament in infant rhesus macaques (Macaca Mulatta): Nonadditive and sex-specific effects.Behavioral neuroscience · 2022Article
- Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus).Scientific reports · 2020Article
- Etiology of Triarchic Psychopathy Dimensions in Chimpanzees (Clinical psychological science : a journal of the Association for Psychological Science · 2017Article
- Article
- Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
- Genetic basis in motor skill and hand preference for tool use in chimpanzees (Pan troglodytes).Proceedings. Biological sciences · 2015Article
- Chimpanzee intelligence is heritable.Current biology : CB · 2014Article
- Genetic influences on receptive joint attention in chimpanzees (Pan troglodytes).Scientific reports · 2014Article
- Systems biology of the vervet monkey.ILAR journal · 2013Review
- A non-human primate system for large-scale genetic studies of complex traits.Human molecular genetics · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Considerable attention has been paid to identifying genetic influences and gene-environment interactions that increase vulnerability to environmental stressors, with promising but inconsistent results. A nonhuman primate model is presented here that allows assessment of genetic influences in response to a stressful life event for a behavioural trait with relevance for psychopathology. Genetic and environmental influences on free-choice novelty seeking behaviour were assessed in a pedigreed colony of vervet monkeys before and after relocation from a low stress to a higher stress environment. Heritability of novelty seeking scores, and genetic correlations within and between environments were conducted using variance components analysis. The results showed that novelty seeking was markedly inhibited in the higher stress environment, with effects persisting across a 2-year period for adults but not for juveniles. There were significant genetic contributions to novelty seeking scores in each year (h(2) = 0.35-0.43), with high genetic correlations within each environment (rhoG > 0.80) and a lower genetic correlation (rhoG = 0.35, non-significant) between environments. There were also significant genetic contributions to individual change scores from before to after the move (h(2) = 0.48). These results indicate that genetic regulation of novelty seeking was modified by the level of environmental stress, and they support a role for gene-environment interactions in a behavioural trait with relevance for mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.