Evidence map›Paper›PMID 21631622›Full record

Trial reportAddiction (Abingdon, England)2011

Treatment outcomes of a stage 1 cognitive-behavioral trial to reduce alcohol use among human immunodeficiency virus-infected out-patients in western Kenya.

Rebecca K Papas, John E Sidle, Benson N Gakinya, Joyce B Baliddawa, Steve Martino, Michael M Mwaniki, Rogers Songole, Otieno E Omolo, Allan M Kamanda, David O Ayuku and 8 more

Registry-linked trialAbstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph

Trial report in Addiction (Abingdon, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00792519 (Alcohol & HIV in Kenya), which is not on this map. Cited by 84 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00792519 phase1completednot on this map

Alcohol & HIV in Kenya: Stage 1 Trial of a Peer-Led Alcohol Behavior Intervention

TypeinterventionalSponsorBrown UniversityRan2009 to 2010Enrolled75ConditionsBinge Drinking, Alcohol Abuse, Alcohol Dependence, HIV InfectionsArmsHIV support group, CBT
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  16. Integrating HIV and substance use services: a systematic review.Journal of the International AIDS Society · 2017
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rebecca K PapasAlpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI 02906,USA. rebecca_papas@brown.edu
John E Sidle
Benson N Gakinya
Joyce B Baliddawa
Steve Martino
Michael M Mwaniki
Rogers Songole
Otieno E Omolo
Allan M Kamanda
David O Ayuku
Claris Ojwang
Willis D Owino-Ong'or
Magdalena Harrington
Kendall J Bryant
Kathleen M Carroll
Amy C Justice
Joseph W Hogan
Stephen A Maisto

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
TSF to enhance treatment of cocaine dependenceP50DA009241 · NIDA · YALE UNIVERSITY · PI CARROLL, KATHLEEN M. · 1994 to 2018
$40.5M
Virology CoreP01AA019072 · NIAAA · BROWN UNIVERSITY · PI BECKER, SARA · 2010 to 2024
$19.7M
New Approaches to Mediation Analysis using Causal Inference MethodsRC1AA019186 · NIAAA · BROWN UNIVERSITY · PI HOGAN, JOSEPH W · 2009 to 2010
$940k
Alcohol & HIV in Kenya: Stage 1 Trial of a Peer-led Alcohol Behavior InterventionR21AA016884 · NIAAA · YALE UNIVERSITY · PI PAPAS, REBECCA K · 2007 to 2008
$329k
NIAAA NIH HHS P01 AA019072NIAAA NIH HHS R21 AA016884NIAAA NIH HHS R21AA016884NIAAA NIH HHS RC1 AA019186NIAID NIH HHS P30 AI042853NIDA NIH HHS P50 DA009241NIDA NIH HHS P50DA09241.
6 · The paper itself

Abstract

aimsDual epidemics of human immunodeficiency virus (HIV) and alcohol use disorders, and a dearth of professional resources for behavioral treatment in sub-Saharan Africa, suggest the need for development of culturally relevant and feasible interventions. The purpose of this study was to test the preliminary efficacy of a culturally adapted six-session gender-stratified group cognitive-behavioral therapy (CBT) intervention delivered by paraprofessionals to reduce alcohol use among HIV-infected out-patients in Eldoret, Kenya.

designRandomized clinical trial comparing CBT against a usual care assessment-only control.

settingA large HIV out-patient clinic in Eldoret, Kenya, part of the Academic Model for Providing Access to Healthcare collaboration.

participantsSeventy-five HIV-infected out-patients who were antiretroviral (ARV)-initiated or ARV-eligible and who reported hazardous or binge drinking. MEASUREMENTS: Percentage of drinking days (PDD) and mean drinks per drinking days (DDD) measured continuously using the Time line Follow back method.

findingsThere were 299 ineligible and 102 eligible out-patients with 12 refusals. Effect sizes of the change in alcohol use since baseline between the two conditions at the 30-day follow-up were large [d=0.95, P=0.0002, mean difference=24.93, 95% confidence interval (CI): 12.43, 37.43 PDD; d=0.76, P=0.002, mean difference=2.88, 95% CI: 1.05, 4.70 DDD]. Randomized participants attended 93% of the six CBT sessions offered. Reported alcohol abstinence at the 90-day follow-up was 69% (CBT) and 38% (usual care). Paraprofessional counselors achieved independent ratings of adherence and competence equivalent to college-educated therapists in the United States. Treatment effect sizes were comparable to alcohol intervention studies conducted in the United States.

conclusionsCognitive-behavioral therapy can be adapted successfully to group paraprofessional delivery in Kenya and may be effective in reducing alcohol use among HIV-infected Kenyan out-patients.

Indexed as

Psychotherapy, GroupAdultAlcohol DrinkingAmbulatory CareCognitive Behavioral TherapyCounselingCultural CharacteristicsEpidemicsFemaleHIV InfectionsHumansKenyaMalePatient ComplianceRegression AnalysisTreatment Outcome

Identifiers

PMID21631622
PMCPMC3208780

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.