Evidence map›Paper›PMID 21631354›Full record

ReviewJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2011

The role of nuclear factor κB in the interferon response.

Lawrence M Pfeffer

Open access · greenAbstract readReview
In one paragraph

Review in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 179 citations in OpenAlex.

  1. Trial
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  4. Beneficial effects of the ATERJ open research · 2026
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  14. Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator.Proceedings of the National Academy of Sciences of the United States of America · 2025
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Lawrence M PfefferDepartment of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA. lpfeffer@uthsc.edu
University of Tennessee Health Science Center · US

Funding

Racial Difference in Hepatitis C Virus-Host Interactions and ResponseU19AI066316 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MARION, TONY N. · 2005 to 2009
$3.0M
Strategies to improve the antiglioma action of IFN-?: a role for NF-kB inhibitionR01CA133322 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DAVIDOFF, ANDREW M, PFEFFER, LAWRENCE MARC · 2009 to 2013
$2.6M
IFNARI SIGNALING THROUGH STAT3, PI 3 KINASER01CA073753 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PFEFFER, LAWRENCE MARC · 1998 to 2007
$2.4M
NCI NIH HHS CA133322NCI NIH HHS CA73753NIAID NIH HHS AI66316
6 · The paper itself

Abstract

The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel interferon (IFN)-activated signaling pathway that leads to NF-κB activation and demonstrate that a subset of IFN-stimulated genes and microRNAs that play key roles in cellular response to IFN is regulated by NF-κB. This review focuses on the IFN-induced NF-κB activation pathway and the role of NF-κB in the expression of IFN-induced coding and noncoding genes, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease.

Indexed as

AnimalsApoptosisBacterial InfectionsGene Expression RegulationHumansImmunity, CellularInterferonsNeoplasmsNF-kappa BSignal TransductionTranscriptional ActivationVirus DiseasesInterferonsNF-kappa B

Identifiers

PMID21631354
PMCPMC3128784
OpenAlexW2091754459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.