ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2012
Treatment of gestational diabetes mellitus: glyburide compared to subcutaneous insulin therapy and associated perinatal outcomes.
Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis.PloS one · 2017Pooled it
- Trial
- Insulin Use During Gestational and Pre-existing Diabetes in Pregnancy: A Systematic Review of Study Design.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Review
- A Clinical Update on Gestational Diabetes Mellitus.Endocrine reviews · 2022Article
- Glycemic control and neonatal outcomes in women with gestational diabetes mellitus treated using glyburide, metformin, or insulin: a pairwise and network meta-analysis.BMC endocrine disorders · 2021Article
- The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy.Current diabetes reports · 2019Review
- Oral Agents for the Treatment of Gestational Diabetes.Current diabetes reports · 2018Review
- Management of sulfonylurea-treated monogenic diabetes in pregnancy: implications of placental glibenclamide transfer.Diabetic medicine : a journal of the British Diabetic Association · 2017Review
- Pharmacological Management of Gestational Diabetes Mellitus.Current diabetes reports · 2016Review
- Predicting failure of glyburide therapy in gestational diabetes.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Comparison of Glibenclamide and Insulin on Neonatal Outcomes in Pregnant Women with Gestational Diabetes.International journal of preventive medicine · 2016Article
- Changing trends in management of gestational diabetes mellitus.World journal of diabetes · 2015Review
- Using oral agents to manage gestational diabetes: what have we learned?Current diabetes reports · 2015Review
- Safety considerations with pharmacological treatment of gestational diabetes mellitus.Drug safety · 2015Review
- A review of current treatment strategies for gestational diabetes mellitus.Drugs in context · 2015Review
- Oral hypoglycemic agents: do the ends justify the means?Maternal health, neonatology and perinatology · 2015Review
- Review of metformin and glyburide in the management of gestational diabetes.Pharmacy practice · 2014Article
- The protective effect of glibenclamide in a model of hemorrhagic encephalopathy of prematurity.Brain sciences · 2013Article
- Gestational diabetes mellitus: what is the optimal treatment modality?Journal of perinatology : official journal of the California Perinatal Association · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine perinatal outcomes in women with gestational diabetes mellitus treated with glyburide compared to insulin injections. STUDY
designThis is a retrospective cohort study of women diagnosed with gestational diabetes mellitus (GDM) who required pharmaceutical therapy and were enrolled in the Sweet Success California Diabetes and Pregnancy Program between 2001 and 2004, a California state-wide program. Women managed with glyburide were compared to women treated with insulin injections. Perinatal outcomes were compared using chi-square test and multivariable logistic regression models; statistical significance was indicated by p < 0.05 and 95% confidence intervals (CI).
resultsAmong the 10,682 women with GDM who required medical therapy and met study criteria, 2073 (19.4%) received glyburide and 8609 (80.6%) received subcutaneous insulin injections. Compared to insulin therapy and controlling for confounders, oral hypoglycemic treatment was associated with increased risk of birthweight >4000 g (aOR = 1.29; 95% CI [1.03-1.64]), and admission to the intensive care nursery (aOR = 1.46 [1.07-2.00]).
conclusionNeonates born to women with gestational diabetes managed on glyburide, and were more likely to be macrosomic and to be admitted to the intensive care unit compared to those treated with insulin injections. These findings should be examined in a large, prospective trial.
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Registered trials
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