ArticleHippocampus2012
Complimentary roles of the hippocampus and retrosplenial cortex in behavioral context discrimination.
Article in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed.
- Retrosplenial cortex codes for permanent landmarks.PloS one · 2012Trial
- Music enhances associative generalization: Evidence from a memory integration task.Memory & cognition · 2026Article
- Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation.Molecular psychiatry · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- The retrosplenial cortical role in delayed spatial alternation.Neurobiology of learning and memory · 2024Article
- Egocentric neural representation of geometric vertex in the retrosplenial cortex.Nature communications · 2024Article
- Learning to use landmarks for navigation amplifies their representation in retrosplenial cortex.bioRxiv : the preprint server for biology · 2024Article
- Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Retrosplenial Cortical Role in Delayed Spatial Alternation.bioRxiv : the preprint server for biology · 2024Article
- Time Cells in the Retrosplenial Cortex.bioRxiv : the preprint server for biology · 2024Article
- The mosaic structure of the mammalian cognitive map.Learning & behavior · 2024Review
- Determination of Neuronal Activity and Its Meaning for the Processes of Learning and Memory.Advances in neurobiology · 2024Review
- Emergence of the Hippocampus as a Vector for Goal-Directed Spatial Navigation.Advances in neurobiology · 2024Review
- Effects of Saffron Extract (AffronNutrients · 2023Article
- Review
- Retrosplenial and Hippocampal Synchrony during Retrieval of Old Memories in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The limbic memory circuit and the neural basis of contextual memory.Neurobiology of learning and memory · 2022Article
- Neural basis of topographical disorientation in the primate posterior cingulate gyrus based on a labeled graph.AIMS neuroscience · 2022Article
- Retrosplenial cortex in spatial memory: focus on immediate early genes mapping.Molecular brain · 2021Review
- Context value updating and multidimensional neuronal encoding in the retrosplenial cortex.Nature communications · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Complex cognitive functions, such as learning and memory, arise from the interaction of multiple brain regions that comprise functional circuits and different components of these circuits make unique contributions to learning. The hippocampus and the retrosplenial cortex (RSC) are anatomically interconnected and both regions are involved in learning and memory. Previous studies indicate that the hippocampus exhibits unique firing patterns for different contexts and that RSC neurons selectively respond to cues that predict reinforcement or the need for a behavioral response, suggesting a hippocampal role in encoding contexts and an RSC role in encoding behaviorally significant cues. To test this, we simultaneously recorded hippocampal and RSC neuronal activity as rats learned to discriminate two behavioral contexts. The rats learned to approach the east arm of a plus maze for reward during the first half of each session and to approach the west arm during the second half. The "go east" and "go west" conditions constitute distinct behavioral contexts, which were cued by the reward location. Neurons in both regions developed highly context-specific responses as subjects learned to discriminate the contexts, but the response patterns differed in the two brain regions. Consistent with a context processing role, hippocampal neurons developed context-specific responses to a variety of task stimuli and events. In contrast, RSC neurons only developed context-specific responses to the reward location, which served as the context identifying cue. These results suggest that the hippocampus and RSC play distinct, but complimentary roles in mediating context appropriate memories and behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.