SynthesisInternational journal of cancer2012
Mammographic density and risk of breast cancer by adiposity: an analysis of four case-control studies.
Synthesis in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Breast Density and Risk of Breast Cancer in Asian Women: A Meta-analysis of Observational Studies.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2016Pooled it
- Breast cancer risk in rheumatoid arthritis: an update meta-analysis.BioMed research international · 2014Pooled it
- Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population.British journal of cancer · 2025Article
- Impact of BMI on Prevalence of Dense Breasts by Race and Ethnicity.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Body Mass Index and Mammographic Density in a Multiracial and Multiethnic Population-Based Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Body mass index, breast density, and the risk of breast cancer development in relation to the menopausal status; results from a population-based screening program in a native African-Arab country.Acta radiologica open · 2022Article
- Association of the Interaction Between Mammographic Breast Density, Body Mass Index, and Menopausal Status With Breast Cancer Risk Among Korean Women.JAMA network open · 2021Observational
- Breast Cancer Population Attributable Risk Proportions Associated with Body Mass Index and Breast Density by Race/Ethnicity and Menopausal Status.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Heterogenous Effect of Risk Factors on Breast Cancer across the Breast Density Categories in a Korean Screening Population.Cancers · 2020Article
- Organoid model of mammographic density displays a higher frequency of aberrant colony formations with radiation exposure.Bioinformatics (Oxford, England) · 2020Article
- Association of Imaging-Based Body Fat Distribution and Mammographic Density in the Multiethnic Cohort Adiposity Phenotype Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Combined effect of volumetric breast density and body mass index on breast cancer risk.Breast cancer research and treatment · 2019Article
- Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype.Breast cancer research : BCR · 2019Article
- Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population.Journal of cancer prevention · 2019Article
- Breast density in multiethnic women presenting for screening mammography.The breast journal · 2018Article
- Correlation of mammographic density and serum calcium levels in patients with primary breast cancer.Cancer medicine · 2017Observational
- Mammographic density and breast cancer risk by family history in women of white and Asian ancestry.Cancer causes & control : CCC · 2015Article
- Methods for assessing and representing mammographic density: an analysis of 4 case-control studies.American journal of epidemiology · 2014Article
- Physical activity and mammographic density in a cohort of postmenopausal Norwegian women; a cross-sectional study.SpringerPlus · 2012Article
- Higher alcohol intake may modify the association between mammographic density and breast cancer: an analysis of three case-control studies.Cancer epidemiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 4 countries.
Funding
Abstract
The association of mammographic breast density with breast cancer risk may vary by adiposity. To examine effect modification by body mass index (BMI), the authors standardized mammographic density data from four case-control studies (1994-2002) conducted in California, Hawaii and Minnesota and Gifu, Japan. The 1,699 cases and 2,422 controls included 45% Caucasians, 40% Asians and 9% African-Americans. Using ethnic-specific BMI cut points, 34% were classified as overweight and 19% as obese. A single reader assessed density from mammographic images using a computer-assisted method. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) while adjusting for potential confounders. Modest heterogeneity in the relation between percent density and breast cancer risk across studies was observed (p(heterogeneity) = 0.08). Cases had a greater age-adjusted mean percent density than controls: 31.7% versus 28.5%, respectively (p <0.001). Relative to <20 percent density, the ORs for >35 were similar across BMI groups whereas the OR for 20-35 was slightly higher in overweight (OR = 1.69, 95% CI: 1.28, 2.24) and obese (OR = 1.62, 95% CI: 1.12, 2.33) than in normal weight women (OR = 1.49, 95% CI: 1.11, 2.01). Furthermore, limited evidence of effect modification by BMI of the OR per 10% increase in percent density (p(interaction) = 0.06) was observed, including subgroup analyses by menopausal status and in analyses that excluded women at the extremes of the BMI scale. Our findings indicate little, if any, modification by BMI of the effects of breast density on breast cancer risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.