ArticleInternational journal of Alzheimer's disease2011
Combining transcranial magnetic stimulation and electroencephalography may contribute to assess the severity of Alzheimer's disease.
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer's disease progression: a systematic review.Alzheimer's research & therapy · 2024Pooled it
- Pooled it
- Cortical excitability and plasticity in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis of transcranial magnetic stimulation studies.Ageing research reviews · 2022Pooled it
- Utilization of Single-Pulse Transcranial-Evoked Potentials in Neurological and Psychiatric Clinical Practice: A Narrative Review.Neurology international · 2024Review
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- TMS-EEG perturbation biomarkers for Alzheimer's disease patients classification.Scientific reports · 2023Article
- TMS-EEG Co-Registration in Patients with Mild Cognitive Impairment, Alzheimer's Disease and Other Dementias: A Systematic Review.Brain sciences · 2021Review
- Neurophysiological Hallmarks of Neurodegenerative Cognitive Decline: The Study of Brain Connectivity as A Biomarker of Early Dementia.Journal of personalized medicine · 2020Review
- On the Use of TMS to Investigate the Pathophysiology of Neurodegenerative Diseases.Frontiers in neurology · 2020Review
- Intermittent theta-burst stimulation induces correlated changes in cortical and corticospinal excitability in healthy older subjects.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Article
- Non-Invasive Brain Stimulation: A New Strategy in Mild Cognitive Impairment?Frontiers in aging neuroscience · 2017Review
- Characterization of Glutamatergic and GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- A combined TMS-EEG study of short-latency afferent inhibition in the motor and dorsolateral prefrontal cortex.Journal of neurophysiology · 2016Article
- Sensorimotor cortex excitability and connectivity in Alzheimer's disease: A TMS-EEG Co-registration study.Human brain mapping · 2016Article
- Cortical function in Alzheimer's disease and frontotemporal dementia.Translational neuroscience · 2016Article
- Characterizing and Modulating Brain Circuitry through Transcranial Magnetic Stimulation Combined with Electroencephalography.Frontiers in neural circuits · 2016Review
- Opportunities for concurrent transcranial magnetic stimulation and electroencephalography to characterize cortical activity in stroke.Frontiers in human neuroscience · 2015Article
- Lasting modulation effects of rTMS on neural activity and connectivity as revealed by resting-state EEG.IEEE transactions on bio-medical engineering · 2014Article
- Synaptic plasticity in neurodegenerative diseases evaluated and modulated by in vivo neurophysiological techniques.Molecular neurobiology · 2012Review
- Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI.Brain topography · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common form of old age dementia, and mild cognitive impairment (MCI) often precedes AD. In our previous study (Julkunen et al. 2008), we found that the combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) was able to find distinct differences in AD and MCI patients as compared to controls. Here, we reanalyzed the small sample data from our previous study with the aim to test the sensitivity of the TMS-EEG characteristics to discriminate control subjects (n = 4) from MCI (n = 5) and AD (n = 5) subjects. Furthermore, we investigated how the TMS-EEG response characteristics related to the scores of the dementia rating scales used to evaluate the severity of cognitive decline in these subjects. We found that the TMS-EEG response P30 amplitude correlated with cognitive decline and showed good specificity and sensitivity in identifying healthy subjects from those with MCI or AD. Given the small sample size, further studies may be needed to confirm the results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.