ArticlePLoS neglected tropical diseases2011
The use of a mobile laboratory unit in support of patient management and epidemiological surveillance during the 2005 Marburg Outbreak in Angola.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Characterization of Mouse-Adapted Marburg and Ravn Viruses in Inbred BALB/c and Outbred CD-1 Mice.The Journal of infectious diseases · 2026Article
- Crystal Structure of Měnglà Virus Nucleoprotein Bound by a Poorly Cross-Reactive Anti-Marburg Virus Nanobody Highlights a Single Amino Acid Affinity Switch, a Feature Also Evident in Dehong Virus.ACS infectious diseases · 2026Article
- Viral RNA persistence and long-term consequences following acute infection with Risk Group 4 zoonotic viruses.Frontiers in cellular and infection microbiology · 2026Review
- Marburg virus outbreak: a global health threat, zoonotic risks, and the urgent need for international action.Virusdisease · 2025Article
- Therapeutic advances in Marburg virus disease: from experimental treatments to vaccine development.Annals of medicine and surgery (2012) · 2025Review
- Validation of a mobile clinical pathology laboratory for canine hematology and biochemistry.BMC veterinary research · 2025Article
- Vacuum Oven Drying: A Cost-Effective Way of Producing Field-Deployable Reagents for In-house Real-Time PCR Methods.Molecular biotechnology · 2025Article
- Existing operational standards for field deployments of rapid response mobile laboratories: a scoping review.Frontiers in public health · 2024Article
- Marburg Virus Outbreak in Equatorial Guinea: Need for Speed.Annals of global health · 2024Article
- Efficiency of Field Laboratories for Ebola Virus Disease Outbreak during Chronic Insecurity, Eastern Democratic Republic of the Congo, 2018-2020.Emerging infectious diseases · 2023Article
- Microbiology laboratories involved in disease and antimicrobial resistance surveillance: Strengths and challenges of the central African states.African journal of laboratory medicine · 2022Review
- A Highly Automated Mobile Laboratory for On-site Molecular Diagnostics in the COVID-19 Pandemic.Clinical chemistry · 2021Article
- Challenges and perspectives on the use of mobile laboratories during outbreaks and their use for vaccine evaluation.Human vaccines & immunotherapeutics · 2019Article
- Introduction of Ebola virus into a remote border district of Sierra Leone, 2014: use of field epidemiology and RNA sequencing to describe chains of transmission.Epidemiology and infection · 2019Article
- New Insights Into Marburg Virus Disease Pathogenesis in the Rhesus Macaque Model.The Journal of infectious diseases · 2018Article
- Ebola Virus Transmission Caused by Persistently Infected Survivors of the 2014-2016 Outbreak in West Africa.The Journal of infectious diseases · 2018Review
- Development of Mobile Laboratory for Viral Hemorrhagic Fever Detection in Africa.The Journal of infectious diseases · 2018Article
- South African Ebola diagnostic response in Sierra Leone: A modular high biosafety field laboratory.PLoS neglected tropical diseases · 2017Article
- Case study: design and implementation of training for scientists deploying to Ebola diagnostic field laboratories in Sierra Leone: October 2014 to February 2016.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Rapid deployment of a mobile biosafety level-3 laboratory in Sierra Leone during the 2014 Ebola virus epidemic.PLoS neglected tropical diseases · 2017Article
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13 authors.
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Abstract
backgroundMarburg virus (MARV), a zoonotic pathogen causing severe hemorrhagic fever in man, has emerged in Angola resulting in the largest outbreak of Marburg hemorrhagic fever (MHF) with the highest case fatality rate to date. METHODOLOGY/PRINCIPAL
findingsA mobile laboratory unit (MLU) was deployed as part of the World Health Organization outbreak response. Utilizing quantitative real-time PCR assays, this laboratory provided specific MARV diagnostics in Uige, the epicentre of the outbreak. The MLU operated over a period of 88 days and tested 620 specimens from 388 individuals. Specimens included mainly oral swabs and EDTA blood. Following establishing on site, the MLU operation allowed a diagnostic response in <4 hours from sample receiving. Most cases were found among females in the child-bearing age and in children less than five years of age. The outbreak had a high number of paediatric cases and breastfeeding may have been a factor in MARV transmission as indicated by the epidemiology and MARV positive breast milk specimens. Oral swabs were a useful alternative specimen source to whole blood/serum allowing testing of patients in circumstances of resistance to invasive procedures but limited diagnostic testing to molecular approaches. There was a high concordance in test results between the MLU and the reference laboratory in Luanda operated by the US Centers for Disease Control and Prevention. CONCLUSIONS/SIGNIFICANCE: The MLU was an important outbreak response asset providing support in patient management and epidemiological surveillance. Field laboratory capacity should be expanded and made an essential part of any future outbreak investigation.
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