Evidence map›Paper›PMID 21629722›Full record

SynthesisPLoS neglected tropical diseases2011

Clinical manifestations associated with neurocysticercosis: a systematic review.

Hélène Carabin, Patrick Cyaga Ndimubanzi, Christine M Budke, Hai Nguyen, Yingjun Qian, Linda Demetry Cowan, Julie Ann Stoner, Elizabeth Rainwater, Mary Dickey

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 9 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 9 syntheses or guidelines pooled it, 340 citations in OpenAlex.

  1. Pooled it
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  4. Anthelmintics for people with neurocysticercosis.The Cochrane database of systematic reviews · 2021
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  12. The effect of albendazole treatment on non-seizure outcomes in patients with symptomatic neurocysticercosis.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2018
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  15. Three decades of neurocysticercosis mandatory notification in a Brazilian endemic region: clinical evolution and severity patterns.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hélène CarabinDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. helene-carabin@ouhsc.edu
Patrick Cyaga Ndimubanzi
Christine M Budke
Hai Nguyen
Yingjun Qian
Linda Demetry Cowan
Julie Ann Stoner
Elizabeth Rainwater
Mary Dickey
University of Oklahoma Health Sciences Center · USTexas A&M University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe clinical manifestations of neurocysticercosis (NCC) are poorly understood. This systematic review aims to estimate the frequencies of different manifestations, complications and disabilities associated with NCC.

methodsA systematic search of the literature published from January 1, 1990, to June 1, 2008, in 24 different electronic databases and 8 languages was conducted. Meta-analyses were conducted when appropriate.

resultsA total of 1569 documents were identified, and 21 included in the analysis. Among patients seen in neurology clinics, seizures/epilepsy were the most common manifestations (78.8%, 95%CI: 65.1%-89.7%) followed by headaches (37.9%, 95%CI: 23.3%-53.7%), focal deficits (16.0%, 95%CI: 9.7%-23.6%) and signs of increased intracranial pressure (11.7%, 95%CI: 6.0%-18.9%). All other manifestations occurred in less than 10% of symptomatic NCC patients. Only four studies reported on the mortality rate of NCC.

conclusionsNCC is a pleomorphic disease linked to a range of manifestations. Although definitions of manifestations were very rarely provided, and varied from study to study, the proportion of NCC cases with seizures/epilepsy and the proportion of headaches were consistent across studies. These estimates are only applicable to patients who are ill enough to seek care in neurology clinics and likely over estimate the frequency of manifestations among all NCC cases.

Indexed as

Attention Deficit Disorder with HyperactivityHeadacheHumansIntracranial HypertensionNeurocysticercosisSeizures

Identifiers

PMID21629722
PMCPMC3101170
OpenAlexW2019796473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.