ArticleJournal of clinical medicine research2010
Adenosine Deaminase Levels in CSF of Tuberculous Meningitis Patients.
Article in Journal of clinical medicine research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Evaluation of Microbiological and Neuroimaging Diagnostic Modalities in Tuberculous Meningitis in Children: A Prospective Observational Study from Rural India.Annals of African medicine · 2026Observational
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- Diagnostic challenges in tuberculous meningitis: a case report with negative genexpert result.Annals of medicine and surgery (2012) · 2023Article
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- Cerebral venous thrombosis and miliary tuberculosis: a case report from Syria.Annals of medicine and surgery (2012) · 2023Article
- Case report long segment myelitis secondary to neuro melioidosis.BMC neurology · 2022Article
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- 10-Year Retrospective Review of the Etiologies for Meningitis With Elevated Adenosine Deaminase in Cerebrospinal Fluid: Etiologies Other Than TB.Frontiers in cellular and infection microbiology · 2022Article
- A study of risk factors for tuberculous meningitis among patients with tuberculosis in China: An analysis of data between 2012 and 2019.Frontiers in public health · 2022Article
- Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches.Journal of clinical microbiology · 2021Review
- Point-of-Care Ultrasound for Extrapulmonary Tuberculosis in India: A Prospective Cohort Study in HIV-Positive and HIV-Negative Presumptive Tuberculosis Patients.The American journal of tropical medicine and hygiene · 2018Article
- Determination and Validation of a Lower Cut Off Value of Cerebrospinal Fluid Adenosine Deaminase (CSF-ADA) Activity in Diagnosis of Tuberculous Meningitis.Journal of clinical and diagnostic research : JCDR · 2017Article
- CSF ADA Determination in Early Diagnosis of Tuberculous Meningitis in HIV-Infected Patients.Scientifica · 2016Article
- Rational application of adenosine deaminase activity in cerebrospinal fluid for the diagnosis of tuberculous meningitis.Infection · 2015Article
- Acute Hypercalcaemia and Hypervitaminosis D in an Infant with Extra Pulmonary Tuberculosis.Journal of clinical and diagnostic research : JCDR · 2015Article
- Prospective Analysis of 55 Cases of Tuberculosis Meningitis (TBM) in North India.Journal of clinical and diagnostic research : JCDR · 2015Article
- Tuberculous meningitis: diagnosis and treatment overview.Tuberculosis research and treatment · 2011Article
- Clinical Profile, Yield of Cartridge-based Nucleic Acid Amplification Test (GeneXpert), and Outcome in Children with Tubercular Meningitis.Journal of pediatric neurosciencesArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis kills five lakh patients in India every year, out of which 7-12 % are with meningeal involvement. Delay in its diagnosis and in initiation of treatment results in poor prognosis and sequlae in up to 25% of cases. The aim of the present study is to look for a simple, rapid, cost effective, non-invasive and fairly specific test in differentiating tubercular etiology from other causes.
methodsForty patients between the age of 6 - 24 months attending hospital with symptoms and signs of meningitis were selected and divided into two groups: tubercular and non-tubercular, depending upon the accepted criteria. CSF was drawn and ADA estimated.
resultsOut of 19 tubercular patients, 18 had CSF ADA at or above the cutoff value while one had below. Out of 21 non-tuberculous patients, two had ADA levels at or above the cutoff value while 19 had below this value. Results of our study indicate that ADA level estimation in CSF is not only of considerable value in the diagnosis of TBM, CSF ADA level 10 U/L as a cutoff value exhibited 94.73% sensitivity and 90.47% specificity in differentiating tuberculous from non-tuberculous meningitis; it also has 90.00% positive predictive value and 95.00% negative predictive value.
conclusionsIt can be concluded that ADA estimation in CSF is not only simple, inexpensive and rapid but also fairly specific method for making a diagnosis of tuberculous etiology in TBM, especially when there is a dilemma of differentiating the tuberculous etiology from non-tuberculous ones. For this reason ADA estimation in TBM may find a place as a routine investigation. KEYWORDS: Cerebrospinal fluid; Adenosine deaminase; Tuberculous meningitis.
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