ArticleSleep2011
Air leak is associated with poor adherence to autoPAP therapy.
Article in Sleep, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05432908 (Effect of Orofacial Myofunctional Therapy on Unintentional Air Leak From the Oral Cavity in Patients With Obstructive Sleep Apnea Treated With Continuous Positive Upper Airway Pressure), which is not on this map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Orofacial Myofunctional Therapy on Unintentional Air Leak From the Oral Cavity in Patients With Obstructive Sleep Apnea Treated With Continuous Positive Upper Airway Pressure (CPAP)
Who cites it
39 citing papers in PubMed.
- What's leak got to do with it? Association of mask leak and positive airway pressure adherence from the homepap study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Trial
- Mask side-effects in long-term CPAP-patients impact adherence and sleepiness: the InterfaceVent real-life study.Respiratory research · 2021Trial
- Comparison of Auto- and Fixed-Continuous Positive Airway Pressure on Air Leak in Patients with Obstructive Sleep Apnea: Data from a Randomized Controlled Trial.Canadian respiratory journal · 2019Trial
- Trial
- Comparing the Efficacy, Mask Leak, Patient Adherence, and Patient Preference of Three Different CPAP Interfaces to Treat Moderate-Severe Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Trial
- Trial
- Impact of Randomization, Clinic Visits, and Medical and Psychiatric Cormorbidities on Continuous Positive Airway Pressure Adherence in Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Trial
- Randomised short-term trial of high-span versus low-span APAP for treating sleep apnoea.Sleep & breathing = Schlaf & Atmung · 2016Trial
- Auto-adjusting positive airway pressure treatment for sleep apnea diagnosed by home sleep testing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Trial
- Nasal versus oronasal continuous positive airway pressure masks for obstructive sleep apnea: a pilot investigation of pressure requirement, residual disease, and leak.Sleep & breathing = Schlaf & Atmung · 2012Trial
- Trial
- Comprehensive Positive Airway Pressure Titration Parameters as Predictors of Therapeutic Adherence in Obstructive Sleep Apnea.Life (Basel, Switzerland) · 2026Article
- A new method using pointing area diagrams to characterize and compare ventilation masks used in continuous positive airway pressure treatment for apneic patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Low-Pressure Heliox-Based Rebreather System to Reduce Work of Breathing and Conserve Gas.Respiratory care · 2025Article
- Impact of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Treatment on Dry Eye Disease: A Systematic Review and Meta-Analysis.Nature and science of sleep · 2024Review
- Case report: An OSAS patient with comorbid RLS/PLMS - a closer look at the causes of PAP intolerance.Frontiers in neurology · 2023Article
- Responses of Bilevel Ventilators to Unintentional Leak: A Bench Study.Healthcare (Basel, Switzerland) · 2022Article
- Continuous Positive Airway Pressure-Mandibular Advancement Device Combination Therapy for Moderate-to-Severe Obstructive Sleep Apnea: A Preliminary Study.European journal of dentistry · 2022Article
- Analysis of risk factors for air leakage in auto-titrating positive airway pressure users: a single-center study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Comparison of airway pressures and expired gas washout for nasal high flow versus CPAP in child airway replicas.Respiratory research · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
STUDY
objectivesTo our knowledge, a systematic study of the effect of air leak on adherence to auto-titrating positive airway pressure (autoPAP) therapy has not been reported. We hypothesized that in patients with obstructive sleep apnea (OSA), greater levels of air leak were associated with poor adherence to autoPAP therapy.
designRetrospective cohort study
settingAcademic Center
participantsNinety-six consecutive patients with high probability for OSA.
interventionsN/A. MEASUREMENTS: Patients with OSA received 1 week of autoPAP therapy following which both adherence data and air leak information was downloaded from the device. Continuous positive airway pressure (CPAP) therapy was issued for a 5-week period with pressure determined by 90th percentile of that delivered during autoPAP therapy. Adequate adherence was defined as average usage > 4 h per night on all nights.
resultsForty-three patients were adherent to autoPAP therapy (350 ± 67[SD] min/day), whereas 53 patients were not (122 ± 65 min/day; P < 0.0001). Air leak that was adjusted for pressure delivered was greater in non-adherent patients (7.0 ± 3.5 L/min/cm H(2)O) than that in adherent patients (4.9 ± 1.7 L/min/cm H(2)O; P < 0.0001). Greater residual respiratory events (measured as autoPAP-derived hypopnea index) and proportion of time spent at large leak levels were associated with non-adherence. Patients who were adherent to autoPAP therapy received higher average therapeutic pressures from the autoPAP device than non-adherent patients. Multivariate logistic regression revealed that higher levels of air leak were associated with non-adherence to autoPAP therapy (odds ratio 1.43; 95% CI, 1.03, 1.98; P = 0.03). Moreover, adherence to autoPAP therapy was strongly correlated with subsequent adherence to CPAP therapy (R(2) = 0.74; P < 0.0001).
conclusionAir leak was associated with poor adherence to autoPAP therapy. We speculate that air leak could be a potential target for future studies aimed at enhancing adherence to autoPAP therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.