ReviewNature reviews. Nephrology2011
Diets and enteral supplements for improving outcomes in chronic kidney disease.
Review in Nature reviews. Nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 82 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Oral Nutritional Supplement Intervention Among Hemodialysis Patients With Sarcopenic Obesity: a Pilot/Feasibility Randomized Controlled Trial
Feeding Pattern and Hypoalbuminemia in Pediatrics With Chronic Kidney Disease.
Validation of the Therapeutic Effect and Safety of a Specialized Oral Supplement on the Nutritional Status and Quality of Life in Patients with Chronic Kidney Disease Without Replacement Therapy: (Grade G3a, G3b, G4 and G5)
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- The Application and Mechanism Analysis of Enteral Nutrition in Clinical Management of Chronic Diseases.Nutrients · 2025Pooled it
- Oral protein-based supplements versus placebo or no treatment for people with chronic kidney disease requiring dialysis.The Cochrane database of systematic reviews · 2020Pooled it
- The Effect of Ketoanalogues on Chronic Kidney Disease Deterioration: A Meta-Analysis.Nutrients · 2019Pooled it
- Trial
- Effect of high-protein meals during hemodialysis combined with lanthanum carbonate in hypoalbuminemic dialysis patients: findings from the FrEDI randomized controlled trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Trial
- Ketoanalogue-Supplemented Vegetarian Very Low-Protein Diet and CKD Progression.Journal of the American Society of Nephrology : JASN · 2016Trial
- Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial.Diabetic medicine : a journal of the British Diabetic Association · 2014Trial
- Effect of hyperinsulinemia during hemodialysis on the insulin-like growth factor system and inflammatory biomarkers: a randomized open-label crossover study.BMC nephrology · 2013Trial
- Association between energy intake and prognosis in Chronic Kidney Disease (CKD) stages 3-5: an ambispective cohort study.Renal failure · 2025Article
- Article
- Development and validation of nomogram and machine learning models to predict sarcopenia in patients with chronic kidney disease.Scientific reports · 2025Article
- Oral Nutritional Supplement Adherence and Nutritional Outcomes in Hemodialysis Patients-A Prospective Study.Journal of clinical medicine · 2025Article
- Association of muscle mass and radiodensity assessed by chest CT with all-cause and cardiovascular mortality in hemodialysis patients.International urology and nephrology · 2024Article
- The Impact of Combined Nutrition and Exercise Interventions in Patients with Chronic Kidney Disease.Nutrients · 2024Review
- Glycemic index of a nutritional supplement designed for people with chronic kidney disease.Food science & nutrition · 2023Article
- The Humoral Response to SARS-CoV-2 Vaccine in Hemodialysis Patients Is Correlated with Nutritional Status.Vaccines · 2023Article
- The Effects of Two Kinds of Dietary Interventions on Serum Metabolic Profiles in Haemodialysis Patients.Biomolecules · 2023Article
- Article
- Effects of the Malnutrition-Eat Additional Meal (MEAM) Diet on the Serum Levels of Albumin and C-Reactive Protein in Hemodialysis Patients.Nutrients · 2022Article
- Association of malnutrition with SARS-CoV-2 vaccine response in patients undergoing hemodialysis.Clinical nutrition (Edinburgh, Scotland) · 2022Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 5 countries.
Funding
Abstract
Protein-energy wasting (PEW), which is manifested by low serum levels of albumin or prealbumin, sarcopenia and weight loss, is one of the strongest predictors of mortality in patients with chronic kidney disease (CKD). Although PEW might be engendered by non-nutritional conditions, such as inflammation or other comorbidities, the question of causality does not refute the effectiveness of dietary interventions and nutritional support in improving outcomes in patients with CKD. The literature indicates that PEW can be mitigated or corrected with an appropriate diet and enteral nutritional support that targets dietary protein intake. In-center meals or oral supplements provided during dialysis therapy are feasible and inexpensive interventions that might improve survival and quality of life in patients with CKD. Dietary requirements and enteral nutritional support must also be considered in patients with CKD and diabetes mellitus, in patients undergoing peritoneal dialysis, renal transplant recipients, and in children with CKD. Adjunctive pharmacological therapies, such as appetite stimulants, anabolic hormones, and antioxidative or anti-inflammatory agents, might augment dietary interventions. Intraperitoneal or intradialytic parenteral nutrition should be considered for patients with PEW whenever enteral interventions are not possible or are ineffective. Controlled trials are needed to better assess the effectiveness of in-center meals and oral supplements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.