ArticleMolecular therapy : the journal of the American Society of Gene Therapy2011
Anti-CD22 antibody targeting of pH-responsive micelles enhances small interfering RNA delivery and gene silencing in lymphoma cells.
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Preparation of siRNA-PLGA/Fab'-PLGA mixed micellar system with target cell-specific recognition.Scientific reports · 2021Article
- pH-Responsive Amphiphilic Carboxylate Polymers: Design and Potential for Endosomal Escape.Frontiers in chemistry · 2021Review
- Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers.Frontiers in chemistry · 2021Review
- Pharmacological Activation of cGAS for Cancer Immunotherapy.Frontiers in immunology · 2021Article
- Fully synthetic macromolecular prodrug chemotherapeutics with EGFR targeting and controlled camptothecin release kinetics.Polymer chemistry · 2018Article
- Enzyme-Cleavable Polymeric Micelles for the Intracellular Delivery of Proapoptotic Peptides.Molecular pharmaceutics · 2017Article
- The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis.Journal of controlled release : official journal of the Controlled Release Society · 2017Review
- Lipidoid nanoparticle mediated silencing of Mcl-1 induces apoptosis in mantle cell lymphoma.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2-overexpressing cancer cells.Oncotarget · 2016Article
- Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists.Bioconjugate chemistry · 2015Review
- Intracellular delivery system for antibody-Peptide drug conjugates.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents.Polymer chemistry · 2015Article
- Dynamic intracellular delivery of antibiotics via pH-responsive polymersomes.Polymer chemistry · 2015Article
- Multifunctional polymeric micelles for delivery of drugs and siRNA.Frontiers in pharmacology · 2014Review
- Neutral polymeric micelles for RNA delivery.Bioconjugate chemistry · 2013Article
- Macrophage-specific RNA interference targeting via "click", mannosylated polymeric micelles.Molecular pharmaceutics · 2013Article
- Immunoconjugates and long circulating systems: origins, current state of the art and future directions.Advanced drug delivery reviews · 2013Review
- Intracellular delivery and trafficking dynamics of a lymphoma-targeting antibody-polymer conjugate.Molecular pharmaceutics · 2012Article
- Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine.Advanced drug delivery reviews · 2012Review
- Application of living free radical polymerization for nucleic acid delivery.Accounts of chemical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The application of small interfering RNA (siRNA) for cancer treatment is a promising strategy currently being explored in early phase clinical trials. However, efficient systemic delivery limits clinical implementation. We developed and tested a novel delivery system comprised of (i) an internalizing streptavidin-conjugated monoclonal antibody (mAb-SA) directed against CD22 and (ii) a biotinylated diblock copolymer containing both a positively charged siRNA condensing block and a pH-responsive block to facilitate endosome release. The modular design of the carrier facilitates the exchange of different targeting moieties and siRNAs to permit its usage in a variety of tumor types. The polymer was synthesized using the reversible addition fragmentation chain transfer (RAFT) technique and formed micelles capable of binding siRNA and mAb-SA. A hemolysis assay confirmed the predicted membrane destabilizing activity of the polymer under acidic conditions typical of the endosomal compartment. Enhanced siRNA uptake was demonstrated in DoHH2 lymphoma and transduced HeLa-R cells expressing CD22 but not in CD22 negative HeLa-R cells. Gene knockdown was significantly improved with CD22-targeted vs. nontargeted polymeric micelles. Treatment of DoHH2 cells with CD22-targeted polymeric micelles containing 15 nmol/l siRNA produced 70% reduction of gene expression. This CD22-targeted polymer carrier may be useful for siRNA delivery to lymphoma cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.