ReviewNature reviews. Urology2011
Differing levels of testosterone and the prostate: a physiological interplay.
Review in Nature reviews. Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Association of spironolactone use with risk of urinary tract cancer in the general population: A matched population-based cohort study.PloS one · 2024Article
- The role of testosterone in men's health: is it time for a new approach?International urology and nephrology · 2022Review
- Engineered reproductive tissues.Nature biomedical engineering · 2020Review
- Androgenic modulation of AR-Vs.Endocrine · 2018Article
- Attenuation of Metabolic Syndrome by EPA/DHA Ethyl Esters in Testosterone-Deficient Obese Rats.Marine drugs · 2018Article
- Impact of metabolic disorders on prostate cancer growth: Androgen and insulin resistance perspectives.Reproductive medicine and biology · 2017Review
- Low Testosterone Alters the Activity of Mouse Prostate Stem Cells.The Prostate · 2017Article
- Relationship Between Aerobic Fitness, the Serum IGF-1 Profiles of Healthy Young Adult African American Males, and Growth of Prostate Cancer Cells.American journal of men's health · 2017Article
- Testosterone Therapy in Patients with Treated and Untreated Prostate Cancer: Impact on Oncologic Outcomes.The Journal of urology · 2016Article
- The treatment of late-onset hypogonadism.Turkish journal of urology · 2014Review
- The safety of testosterone supplementation therapy in prostate cancer.Nature reviews. Urology · 2014Review
- Association of serum calcium with serum sex steroid hormones in men in NHANES III.The aging male : the official journal of the International Society for the Study of the Aging Male · 2013Article
- Diabetes protects from prostate cancer by downregulating androgen receptor: new insights from LNCaP cells and PAC120 mouse model.PloS one · 2013Article
- Low systemic testosterone levels induce androgen maintenance in benign rat prostate tissue.Journal of molecular endocrinology · 2013Article
- Testosterone replacement therapy and prostate health.Current urology reports · 2012Article
- Stimulation of a non-functioning pituitary macroadenoma after administration of goserelin acetate for locally advanced prostate cancer causing a sustained elevation in PSA and testosterone.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The controversies surrounding testosterone replacement therapy (TRT) have been addressed in the past few years. Although the androgenic effects of TRT on normal and malignant prostate cells have been studied for over 70 years, little clinical prospective research exists on the physiological responses of prostate tissues to a wide range of serum testosterone levels. The prostate is both an androgen-dependent and an androgen-sensitive organ; active processes are triggered at a 'threshold' or 'saturation' level of testosterone. Despite decades of research, no compelling evidence exists that increasing testosterone beyond this threshold level has a causative role in prostate cancer, or indeed changes the biology of the prostate. Testosterone deficiency has marked physiological and clinical effects on men in middle age and beyond. With subnormal testosterone levels, the potential positive benefits of TRT on factors such as muscle mass, libido or erectile function are likely a dose-response phenomenon, and should be considered differently than the threshold influence on the prostate. This Review will re-examine classic androgen research and reflect on whether testosterone actually stimulates prostatic cellular growth and progression in a 'threshold' or a 'dose-response' (or both) manner, as well as discuss the influence of testosterone on prostate cells in the hypogonadal and eugonadal states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.