ArticleThe American journal of the medical sciences2011
Variants and haplotypes in angiotensinogen gene are associated with plasmatic angiotensinogen level in Mexican population.
Article in The American journal of the medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Myocardial Infarction andCardiovascular therapeutics · 2021Pooled it
- T174M-M235TCurrent issues in molecular biology · 2026Article
- Genome-wide association study of angiotensinogen levels and key single nucleotide polymorphism associations with blood pressure.Journal of hypertension · 2025Article
- Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma.PloS one · 2018Article
- Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population.Clinical hypertension · 2017Article
- Haplotype analysis of TLR4 gene and its effects on milk somatic cell score in Chinese commercial cattle.Molecular biology reports · 2014Article
- Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel.PloS one · 2013Article
- Hypercontrols in genotype-phenotype analysis reveal ancestral haplotypes associated with essential hypertension.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Contribution of angiotensinogen M235T and T174M gene variants and haplotypes to preeclampsia and its severity in (North African) Tunisians.Journal of the renin-angiotensin-aldosterone system : JRAASArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe plasmatic angiotensinogen (AGT) level has been associated with essential hypertension. Linkage analysis has found a relationship between the AGT gene locus and hypertension in the Mexican-American population, but studies have failed to identify genetic variants associated with hypertension or plasma AGT levels. This study analyzes the relationship between polymorphisms in the AGT gene and plasmatic AGT levels in Mexican population.
methodsNine polymorphisms in AGT gene were genotyped, and plasma AGT level was determined by enzyme-linked immunosorbent assay.
resultsDifferences in AGT plasma levels were associated with 2 polymorphisms: T-20G, TT = 25.3 ± 8.3 versus TG + GG = 21.6 ± 8.8 μg/mL; P = 0.008 and C3389T (T174M), CC = 25.8 ± 9.9 versus TC + TT = 20.5 ± 5.4 μg/mL; P = 0.0002. Haplotype 2 was associated with low plasma AGT (-5.1 μg/mL [95% confidence interval: -8.6 to -1.6], P = 0.004) and Haplotype 8 was associated with high plasma AGT (6.5 μg/mL [95% confidence interval: 2.5 to 10.6], P = 0.001). This association remained after adjustment for covariates. A Likelihood Ratio Test for haplotype-phenotype association adjusted for covariates resulted in χ = 38.9, P = 0.0005. The total effect of the haplotypes on plasma AGT level variance was 19.5%. No association was identified between haplotypes and quantitative traits of blood pressure.
conclusionsTwo polymorphisms (T-20G and C3389T) and 2 haplotypes (H2 and H8) showed an association with plasma AGT levels in Mexican population.
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