ArticleJournal of child neurology2011
A prospective outcome study of neonatal cerebral sinovenous thrombosis.
Article in Journal of child neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04508517 (A Cohort Study on the Etiology and Pathological Types of Brain White Matter Injury in Late Preterm Infants), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Cohort Study on the Etiology and Pathological Types of Brain White Matter Injury in Late Preterm Infants
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Perinatal arterial ischemic stroke (PAIS) and neonatal cerebral sinovenous thrombosis (CSVT) in the preterm neonate: a systematic review.Pediatric research · 2026Pooled it
- Treatment of pediatric cerebral venous sinus thromboses: the role of anticoagulation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Pooled it
- Venous Thromboembolism in Neonates, Children, and Adolescents: A Comprehensive Narrative Review of Risk Factors, Diagnosis, Treatment, and Prevention.Medicina (Kaunas, Lithuania) · 2026Review
- Neonatal Thromboembolic Disease: Clinical Spectrum and Emerging Evidence for Diagnostic and Therapeutic Strategies Addressing Unmet Needs.Journal of clinical medicine · 2026Review
- Venous-significant intracranial hemorrhage in neonatal HIE treated with therapeutic hypothermia: imaging phenotypes, diagnostic pitfalls, and prognostic implications.Frontiers in neuroscience · 2026Review
- Radiographic Severity of Neonatal Deep Medullary Venous Thrombosis is Associated with Neurodevelopmental Impairment.The Journal of pediatrics · 2025Article
- Early Enoxaparin Treatment in a Newborn with Cerebral Venous Sinus Thrombosis and Acute Cerebellar Hemorrhage.AJP reports · 2025Article
- Early detection of cerebral sinus venous thrombosis in an extremely low birth weight infant using cranial ultrasound-case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Balancing safety and efficacy of low-molecular-weight heparins in neonates: a systematic review.Research and practice in thrombosis and haemostasis · 2024Review
- The Hemostatic System in Newborns and the Risk of Neonatal Thrombosis.International journal of molecular sciences · 2023Review
- Cerebral venous sinus thrombosis and skull base osteomyelitis as manifestations of cat-scratch disease in a pediatric patient: A case report and literature review.Clinical case reports · 2023Article
- Magnetic resonance venography to evaluate cerebral sinovenous thrombosis in infants receiving therapeutic hypothermia.Pediatric research · 2023Article
- Research advances in neonatal cerebral sinovenous thrombosis.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Review
- Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment.Journal of child neurology · 2021Observational
- Cerebral sinovenous thrombosis in children: A single-center experience.Turkish archives of pediatrics · 2021Article
- Seizures and Outcome One Year After Neonatal and Childhood Cerebral Sinovenous Thrombosis.Pediatric neurology · 2020Article
- Epidemiology of neonatal stroke: A population-based study.Paediatrics & child health · 2020Article
- An Important Finding of White Matter Injury in Late Preterm Infant: Deep Medullary Vein Involvement.Frontiers in pediatrics · 2020Article
- MR Imaging Scoring System for White Matter Injury after Deep Medullary Vein Thrombosis and Infarction in Neonates.AJNR. American journal of neuroradiology · 2019Article
- Neonatal Vein of Labbé Infarction Size is Associated With Long-Term Language Outcomes.Pediatric neurology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Neonatal cerebral sinovenous thrombosis is a frequent contributor to neonatal mortality and morbidity. Treatment is controversial, and reported clinical outcomes vary widely. Newborns with radiologically confirmed neonatal cerebral sinovenous thrombosis from 1992 to 2009 were prospectively followed in our Children's Stroke Clinic for standardized outcomes, including the Pediatric Stroke Outcome Measure. Outcomes were available in 90 of 104 (87%) neonates. Early outcomes included cerebral sinovenous thrombosis-associated death (5) and thrombus propagation (15 [6 associated with new venous infarcts]). Lack of anticoagulation predicted propagation (RR = 13; P = .0007). Complete thrombus recanalization occurred in 90% by 3 months. Late outcomes (median, 2.5 years) were epilepsy (15) and neurological disability (50), which included moderate-severe language (43), sensorimotor (38), and cognitive/behavioral (24) deficits. Overall, 61% had poor outcome (death/any deficit). Concurrent neurological comorbidity at diagnosis (odds ratio = 2.8; P = .029) predicted poor outcome. Clinical trials are urgently needed to establish more effective treatment strategies.
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