ArticleThe Journal of infectious diseases2011
Invasion of erythrocytes by Francisella tularensis.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A slow decay to extinction: cold temperatures and reduced microbial complexity prolong the persistence of planktonicApplied and environmental microbiology · 2026Article
- Host-pathogen interactions involved in erythrocyte invasion byFrontiers in cellular and infection microbiology · 2025Article
- Identification of an N-terminal tag (580N) that improves the biosynthesis of fluorescent proteins in Francisella tularensis and other Gram-negative bacteria.Molecular and cellular probes · 2024Article
- Mutation ofMicrobiology (Reading, England) · 2024Article
- Phenotypic and transcriptional characterization ofFrontiers in microbiology · 2024Article
- Article
- Circulating T Cells Are Not Sufficient for Protective Immunity against VirulentJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- PdpC, a secreted effector protein of the type six secretion system, is required for erythrocyte invasion byFrontiers in cellular and infection microbiology · 2022Article
- OpiA, a Type Six Secretion System Substrate, Localizes to the Cell Pole and Plays a Role in Bacterial Growth and Viability inJournal of bacteriology · 2020Article
- The Healthy Human Blood Microbiome: Fact or Fiction?Frontiers in cellular and infection microbiology · 2019Review
- No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.Biological reviews of the Cambridge Philosophical Society · 2018Review
- The Role and Mechanism of Erythrocyte Invasion byFrontiers in cellular and infection microbiology · 2017Article
- FmvB: A Francisella tularensis Magnesium-Responsive Outer Membrane Protein that Plays a Role in Virulence.PloS one · 2016Article
- Temperature-Dependent Gentamicin Resistance of Francisella tularensis is Mediated by Uptake Modulation.Frontiers in microbiology · 2016Article
- The dormant blood microbiome in chronic, inflammatory diseases.FEMS microbiology reviews · 2015Review
- Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology.F1000Research · 2015Review
- The Characterization of Novel Tissue Microbiota Using an Optimized 16S Metagenomic Sequencing Pipeline.PloS one · 2015Article
- Entry of Francisella tularensis into Murine B Cells: The Role of B Cell Receptors and Complement Receptors.PloS one · 2015Article
- Brucella melitensis invades murine erythrocytes during infection.Infection and immunity · 2014Article
- Erythrocyte and blood antibacterial defense.European journal of microbiology & immunology · 2014Article
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6 authors.
Funding
Abstract
Francisella tularensis is the causative agent of tularemia and is classified as a category A biodefense agent by the Centers for Disease Control and Prevention because of its highly infectious nature. F. tularensis infects leukocytes and exhibits an extracellular phase in the blood of the host. It is unknown, however, whether F. tularensis can infect erythrocytes; thus, we examined this possibility in vivo and in vitro. In the murine model of pulmonary type A tularemia, we showed the presence of intraerythrocytic bacteria by double-immunofluorescence microscopy and ex vivo gentamicin protection of the purified erythrocyte fraction. In vitro, F. tularensis invaded human erythrocytes, as shown in the gentamicin protection assays, double-immunofluorescence microscopy, flow cytometry, scanning electron microscopy, and transmission electron microscopy with immunogold labeling of the bacteria. Additional in vitro tests indicated that serum complement-dependent and complement-independent mechanisms contribute to erythrocyte invasion. Our results reveal a novel intraerythrocytic phase during F. tularensis infection.
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