ArticleThe Journal of infectious diseases2011
An experimental mouse model to establish Tropheryma whipplei as a diarrheal agent.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Multidisciplinary management of Whipple's disease complicated with rectal stenosis from multidisciplinary nursing management: A case study.Pakistan journal of medical sciences · 2026Article
- Pulmonary infection caused byTranslational pediatrics · 2026Article
- Human genetics of Whipple's disease.Current opinion in rheumatology · 2025Review
- A case of pneumonia caused by infection with Tropheryma whipplei complicated by cryptococcus during treatment with a Janus kinase inhibitor: a case report.BMC pulmonary medicine · 2024Article
- Severe pneumonia in adults caused by Tropheryma whipplei and Candida sp. infection: a 2019 case series.BMC pulmonary medicine · 2021Article
- Intrafamilial circulation of Tropheryma whipplei, France.Emerging infectious diseases · 2012Article
- Article
- Tropheryma whipplei: a common bacterium in rural Senegal.PLoS neglected tropical diseases · 2011Article
- Whipple disease research accelerates.The Journal of infectious diseases · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tropheryma whipplei has long been considered as a rare bacterium causing a rare disease, Whipple's disease. However, recent advances now suggest that T. whipplei is a ubiquitous environmental bacterium that may cause gastroenteritis, commonly associated with viral pathogens. We developed an animal model to support this hypothesis. We found that orally given T. whipplei induced diarrhea in mice, without spreading into the intestines. Aggravating factors, such as damage to the intestinal mucosa, favored bacterial spreading. Indeed, bacterial presence was prolonged in stools of dextran sulfate-treated mice, and bacteria were detected in the colon. This resulted in an immune response, with T. whipplei-specific serum IgM and IgG and fecal IgA, as measured by newly introduced immuno-polymerase chain reaction technique. Our results confirm that T. whipplei is an agent causing gastroenteritis and suggest that existing mucosal damage may favor bacterial invasion of tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.