ArticleProceedings of the National Academy of Sciences of the United States of America2011
In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 87 citations in OpenAlex.
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- Identification and analysis of pancreatic intraepithelial neoplasia: opportunities and challenges.Frontiers in endocrinology · 2024Review
- Bendable long graded index lens microendoscopy.Optics express · 2022Article
- Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice.EBioMedicine · 2022Article
- Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer.Cancer discovery · 2021Article
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- Near-Infrared-II Molecular Dyes for Cancer Imaging and Surgery.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer.Nature communications · 2018Article
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- Precancer Atlas to Drive Precision Prevention Trials.Cancer research · 2017Article
- Identification of liver metastases with probe-based confocal laser endomicroscopy at two excitation wavelengths.Lasers in surgery and medicine · 2017Article
- Fibered Confocal Fluorescence Microscopy for the Noninvasive Imaging of Langerhans Cells in Macaques.Contrast media & molecular imaging · 2017Article
- Fluorescence lifetime measurement with confocal endomicroscopy for direct analysis of tissue biochemistry in vivo.Heliyon · 2016Article
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- Genetics and biology of pancreatic ductal adenocarcinoma.Genes & development · 2016Review
- Confocal laser endomicroscopy to monitor the colonic mucosa of mice.Journal of immunological methods · 2015Article
- Fluorescence-Raman dual modal endoscopic system for multiplexed molecular diagnostics.Scientific reports · 2015Article
- New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal pH metry in extraesophageal gastroesophageal reflux disease.World journal of gastroenterology · 2015Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with poor patient outcome often resulting from late diagnosis in advanced stages. To date methods to diagnose early-stage PDAC are limited and in vivo detection of pancreatic intraepithelial neoplasia (PanIN), a preinvasive precursor of PDAC, is impossible. Using a cathepsin-activatable near-infrared probe in combination with flexible confocal fluorescence lasermicroscopy (CFL) in a genetically defined mouse model of PDAC we were able to detect and grade murine PanIN lesions in real time in vivo. Our diagnostic approach is highly sensitive and specific and proved superior to clinically established fluorescein-enhanced imaging. Translation of this endoscopic technique into the clinic should tremendously improve detection of pancreatic neoplasia, thus reforming management of patients at risk for PDAC.
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