ArticleBMC physiology2011
Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms.
Article in BMC physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoEAngiogenesis · 2024Article
- Role of HOXA1-4 in the development of genetic and malignant diseases.Biomarker research · 2024Review
- Epigenome-wide association study using peripheral blood leukocytes identifies genomic regions associated with periodontal disease and edentulism in the Atherosclerosis Risk in Communities study.Journal of clinical periodontology · 2023Article
- Locational memory of macrovessel vascular cells is transcriptionally imprinted.Scientific reports · 2023Article
- Gene Expression Profiling in Abdominal Aortic Aneurysms.Journal of clinical medicine · 2022Article
- Interleukin 12p40 Deficiency Promotes Abdominal Aortic Aneurysm by Activating CCN2/MMP2 Pathways.Journal of the American Heart Association · 2021Article
- Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity.EMBO reports · 2020Article
- Differentially expressed genes and canonical pathways in the ascending thoracic aortic aneurysm - The Tampere Vascular Study.Scientific reports · 2017Article
- RNAi therapy to the wall of arteries and veins: anatomical, physiologic, and pharmacological considerations.Journal of translational medicine · 2017Review
- Topographic patterns of vascular disease: HOX proteins as determining factors?World journal of biological chemistry · 2015Article
- Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm.International journal of molecular sciences · 2015Article
- SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.Scientific reports · 2015Article
- Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms.International journal of molecular sciences · 2015Article
- The potential role of DNA methylation in abdominal aortic aneurysms.International journal of molecular sciences · 2015Article
- Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model.Journal of the American Heart Association · 2014Article
- Gene expression profiling in subcutaneous, visceral and epigastric adipose tissues of patients with extreme obesity.International journal of obesity (2005) · 2014Article
- Review
- A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass.Diabetes care · 2013Article
- New Insights Into Aortic Diseases: A Report From the Third International Meeting on Aortic Diseases (IMAD3).Aorta (Stamford, Conn.) · 2013Article
- Interpreting inflammation: smooth muscle positional identity and nuclear factor-κB signaling.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
Corrections and comments
- Commented on by
Authors and funding
20 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe infrarenal abdominal aorta exhibits increased disease susceptibility relative to other aortic regions. Allograft studies exchanging thoracic and abdominal segments showed that regional susceptibility is maintained regardless of location, suggesting substantial roles for embryological origin, tissue composition and site-specific gene expression.
resultsWe analyzed gene expression with microarrays in baboon aortas, and found that members of the HOX gene family exhibited spatial expression differences. HOXA4 was chosen for further study, since it had decreased expression in the abdominal compared to the thoracic aorta. Western blot analysis from 24 human aortas demonstrated significantly higher HOXA4 protein levels in thoracic compared to abdominal tissues (P < 0.001). Immunohistochemical staining for HOXA4 showed nuclear and perinuclear staining in endothelial and smooth muscle cells in aorta. The HOXA4 transcript levels were significantly decreased in human abdominal aortic aneurysms (AAAs) compared to age-matched non-aneurysmal controls (P < 0.00004). Cultured human aortic endothelial and smooth muscle cells stimulated with INF-γ (an important inflammatory cytokine in AAA pathogenesis) showed decreased levels of HOXA4 protein (P < 0.0007).
conclusionsOur results demonstrated spatial variation in expression of HOXA4 in human aortas that persisted into adulthood and that downregulation of HOXA4 expression was associated with AAAs, an important aortic disease of the ageing population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.