ArticleInvestigative genetics2011
Multiplex single-nucleotide polymorphism typing of the human Y chromosome using TaqMan probes.
Article in Investigative genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Overview of Genotyping Technologies and Methods.Current protocols · 2023Article
- Origins, admixture and founder lineages in European Roma.European journal of human genetics : EJHG · 2016Article
- Y-chromosome diversity in Catalan surname samples: insights into surname origin and frequency.European journal of human genetics : EJHG · 2015Article
- Genetic Heterogeneity in Algerian Human Populations.PloS one · 2015Article
- Inferring population structure and relationship using minimal independent evolutionary markers in Y-chromosome: a hybrid approach of recursive feature selection for hierarchical clustering.Nucleic acids research · 2014Article
- Contemporary paternal genetic landscape of Polish and German populations: from early medieval Slavic expansion to post-World War II resettlements.European journal of human genetics : EJHG · 2013Article
- Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata.PloS one · 2013Article
- Y-chromosome analysis in individuals bearing the Basarab name of the first dynasty of Wallachian kings.PloS one · 2012Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundThe analysis of human Y-chromosome variation in the context of population genetics and forensics requires the genotyping of dozens to hundreds of selected single-nucleotide polymorphisms (SNPs). In the present study, we developed a 121-plex (121 SNPs in a single array) TaqMan array capable of distinguishing most haplogroups and subhaplogroups on the Y-chromosome human phylogeny in Europe.
resultsWe present data from 264 samples from several European areas and ethnic groups. The array developed in this study shows >99% accuracy of assignation to the Y human phylogeny (with an average call rate of genotypes >96%).
conclusionsWe have created and evaluated a robust and accurate Y-chromosome multiplex which minimises the possible errors due to mixup when typing the same sample in several independent reactions.
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Registered trials
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