ArticleBMC pulmonary medicine2011
Antibiotic consumption in children prior to diagnosis of asthma.
Article in BMC pulmonary medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Association between use of antibacterial agents in the first year of life and childhood asthma: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Pooled it
- Antibiotic treatment for non-specific upper respiratory tract infections and exacerbation risk in children with asthma: a target trial emulation study.American journal of epidemiology · 2026Article
- Postnatal pediatric systemic antibiotic episodes during the first three years of life are not associated with mode of delivery.PloS one · 2020Article
- Trends in Antibiotic Use by Birth Season and Birth Year.Pediatrics · 2017Article
- Neonatal monocytes exhibit a unique histone modification landscape.Clinical epigenetics · 2016Article
- Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis.BMJ (Clinical research ed.) · 2014Article
- Can appropriate diagnosis and treatment of childhood asthma reduce excessive antibiotic usage?Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2014Article
- Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: a dose-dependent relationship.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Article
- The case of drug causation of childhood asthma: antibiotics and paracetamol.European journal of clinical pharmacology · 2013Review
- From Birth to "Immunohealth," Allergies and Enterocolitis.Journal of clinical gastroenterologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAsthma is difficult to diagnose in children and at times misdiagnosis of an infection can occur. However, little is known about the magnitude and patterns of antibiotic consumption in children with asthma relative to those without asthma.
methodsUsing population-based data, 128,872 children were identified with at least 6 years of follow-up. The adjusted rate-ratio (RR) of antibiotics dispensed to asthmatic as compared to non-asthmatic children was determined.
resultsAt age six, the RR of antibiotic consumption for asthmatics compared to non-asthmatics varied between, 1.66 to 2.32, depending on the year of asthma diagnosis. Of the 18,864 children with asthma at ages 2-8, 52% (n = 9,841) had antibiotics dispensed in the 6 months prior to their index date of asthma diagnosis. The RR of antibiotic consumption in the 1 month prior to asthma diagnosis compared to 5 months prior was 1.66 (95% CI 1.60-1.71). The RR was lower in males compared to females (1.58 vs 1.77), and lower in those who received antibiotics in the first year of life relative to those that did not (1.60 vs. 1.76).
conclusionsThere is higher antibiotic consumption in children with asthma compared to those without asthma. The pattern of antibiotic use suggests that diagnosis guidelines are difficult to follow in young children leading to misdiagnosis and over treatment with antibiotics.
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