ArticleMicrocirculation (New York, N.Y. : 1994)2011
Angiogenesis in mesenteric microvascular networks from spontaneously hypertensive versus normotensive rats.
Article in Microcirculation (New York, N.Y. : 1994), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury.Journal of vascular research · 2022Article
- Microvascular dysfunction and kidney disease: Challenges and opportunities?Microcirculation (New York, N.Y. : 1994) · 2021Review
- Induction of microvascular network growth in the mouse mesentery.Microcirculation (New York, N.Y. : 1994) · 2018Article
- A Novel ex vivo Mouse Mesometrium Culture Model for Investigating Angiogenesis in Microvascular Networks.Journal of vascular research · 2018Article
- Aging is associated with impaired angiogenesis, but normal microvascular network structure, in the rat mesentery.American journal of physiology. Heart and circulatory physiology · 2017Article
- Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research: Focus on Hypertension and Diabetes.Translational stroke research · 2016Review
- Granulocyte colony-stimulating factor (G-CSF) treatment in combination with transplantation of bone marrow cells is not superior to G-CSF treatment alone after cortical stroke in spontaneously hypertensive rats.Frontiers in cellular neuroscience · 2014Article
- An angiogenesis model for investigating multicellular interactions across intact microvascular networks.American journal of physiology. Heart and circulatory physiology · 2013Article
- Relationships between lymphangiogenesis and angiogenesis during inflammation in rat mesentery microvascular networks.Lymphatic research and biology · 2012Article
- Cell proliferation along vascular islands during microvascular network growth.BMC physiology · 2012Article
- The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats.Medical & biological engineering & computing · 2012Article
- Rat mesentery exteriorization: a model for investigating the cellular dynamics involved in angiogenesis.Journal of visualized experiments : JoVE · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveElevated blood pressure during hypertension has been associated with microvascular rarefaction, defined as a loss of microvessels. However, whether rarefaction is a result of impaired angiogenesis remains unclear. The objective of this study was to compare angiogenesis across the time course of mesenteric microvascular network remodeling in adult spontaneously hypertensive versus normotensive rats.
methodsAngiogenic responses in 15- to 16-week-old SHR and Wistar rats at 0, 3, 5, 10 or 25 days post 20-minute exteriorization of the mesentery were quantified.
resultsConsistent with the phenomenon of rarefaction, vascularized area in unstimulated SHR was decreased compared to Wistar. By 25 days, SHR vascular area had increased to the Wistar level and vascular length density and capillary sprouting were comparable. At 3 and 5 days, SHR and Wistar tissues displayed an increase in the capillary sprouting and vascular density relative to their unstimulated controls. At 10 days, capillary sprouting in the SHR remained elevated. The percent change in vascular density was elevated in the SHR compared to the Wistar group at 3 and 5 days and by 25 days the rate of change was more negative.
conclusionsOur results suggest that SHR networks undergo an increased rate of growth followed by an increased rate of pruning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.