ArticlePediatric pulmonology2011
Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: comparison with pediatric pneumonia without H1N1 2009 infection.
Article in Pediatric pulmonology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Cytokine Concentrations in Plasma from Children with Severe and Non-Severe Community Acquired Pneumonia.PloS one · 2015Trial
- Mathematical Model of Influenza Infection Suggests JAK-STAT Activity Drives Severe Pathologies in Juvenile Mice.Frontiers in applied mathematics and statistics · 2025Article
- Deciphering SARS-CoV-2 Virologic and Immunologic Features.International journal of molecular sciences · 2020Review
- Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure.Open forum infectious diseases · 2020Article
- Th17 serum cytokines in relation to laboratory-confirmed respiratory viral infection: A pilot study.Journal of medical virology · 2019Article
- Biomarkers of Community-Acquired Pneumonia: A Key to Disease Diagnosis and Management.BioMed research international · 2019Review
- Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Comparison of cytokine expression profiles in infants with a rhinovirus induced lower respiratory tract infection with or without wheezing: a comparison with respiratory syncytial virus.Korean journal of pediatrics · 2017Article
- A Role for Neutrophils in Viral Respiratory Disease.Frontiers in immunology · 2017Review
- Analysis of clinical value of CT in the diagnosis of pediatric pneumonia and mycoplasma pneumonia.Experimental and therapeutic medicine · 2016Article
- Influenza A Virus Infection, Innate Immunity, and Childhood.JAMA pediatrics · 2015Review
- Mucosal immune responses predict clinical outcomes during influenza infection independently of age and viral load.American journal of respiratory and critical care medicine · 2014Article
- Clinical aspects and cytokine response in adults with seasonal influenza infection.International journal of clinical and experimental medicine · 2014Article
- Hantaan virus infection induces CXCL10 expression through TLR3, RIG-I, and MDA-5 pathways correlated with the disease severity.Mediators of inflammation · 2014Article
- Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system.Pediatric rheumatology online journal · 2013Article
- Innate immune function and mortality in critically ill children with influenza: a multicenter study.Critical care medicine · 2013Article
- Modulation of murine macrophage TLR7/8-mediated cytokine expression by mesenchymal stem cell-conditioned medium.Mediators of inflammation · 2013Article
- Article
- Two years after pandemic influenza A/2009/H1N1: what have we learned?Clinical microbiology reviews · 2012Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe investigated serum cytokine levels in pediatric patients with pandemic influenza H1N1 2009 virus (H1N1) infection-pneumonia and in pediatric patients with pneumonia but without H1N1 infection, and examined correlations between cytokine levels and clinical/laboratory findings.
methodsFifty-seven cases of infection by H1N1 were confirmed by RT-PCR and enrolled. Of these 57 cases, 26 had a severe H1N1 infection (group 1), and 31 had a mild H1N1 infection (group 2). Sera from 18 cases with pneumonia without H1N1 infection (group 3) were used as controls. The serum levels of 10 cytokines were determined by multiplex assay.
resultsThe serum levels of IFN-α, IL-6, and IP-10 were significantly higher in H1N1 infected cases than in group 3, and levels of IL-6 and IP-10 were significantly higher in group 1 than in group 2. The level of IL-10 was significantly higher in groups 1 and 3 than in group 2. However, levels of IFN-γ and IL-17 were not significantly different between the three groups. IL-1β, IL-4, and MIP-1α were not detectable in most patients. IP-10 and IL-6 levels were found to show negative correlations with lymphocyte count and oxygen saturation.
conclusionsWe found higher levels of cytokines (IFN-α, IL-6, IP-10) of innate immunity than those of acquired immunity in pediatric H1N1 infection. Of the cytokines found to be increased in cases with H1N1 infection, IP-10 and IL-6 were found to be correlated with disease severity (lymphopenia and hypoxia). IP-10 and IL-6 may be important markers in pediatric H1N1 infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.