ArticleJournal of behavioral medicine2012
Co-occurrence of obesity and patterns of alcohol use associated with elevated serum hepatic enzymes in US adults.
Article in Journal of behavioral medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- KASL clinical practice guidelines: management of alcoholic liver disease.Clinical and molecular hepatology · 2013Guideline
- Association between lifestyle factors and liver function parameters in the middle-aged and older population.BMC public health · 2025Article
- Associations between per- and polyfluoroalkyl substances, liver function, and daily alcohol consumption in a sample of U.S. adults.Environmental research · 2023Article
- Associations between Liver Enzymes, Lifestyle Risk Factors and Pre-Existing Medical Conditions in a Population-Based Cross-Sectional Sample.Journal of clinical medicine · 2023Article
- In vitro, in vivo, and in silico analysis of synbiotics as preventive interventions for lipid metabolism in ethanol-induced adipose tissue injury.Lipids in health and disease · 2023Article
- Decomposition of the total effect for two mediators: A natural mediated interaction effect framework.Journal of causal inference · 2022Article
- Animal Evidence for Synergistic Induction of Hepatic Injury by Dietary Fat and Alcohol Consumption and Its Potential Mechanisms.Journal of personalized medicine · 2021Article
- Impacts of unfavourable lifestyle factors on biomarkers of liver function, inflammation and lipid status.PloS one · 2019Article
- A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels.International journal of hepatology · 2018Article
- Trauma injury in adult underweight patients: A cross-sectional study based on the trauma registry system of a level I trauma center.Medicine · 2017Article
- Where should the safe limits of alcohol consumption stand in light of liver enzyme abnormalities in alcohol consumers?PloS one · 2017Article
- Serum γ-Glutamyltransferase, Alanine Aminotransferase and Aspartate Aminotransferase Activity in Healthy Blood Donor of Different Ethnic Groups in Gorgan.Journal of clinical and diagnostic research : JCDR · 2016Article
- Obese motorcycle riders have a different injury pattern and longer hospital length of stay than the normal-weight patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2016Article
- Traumatic injuries among adult obese patients in southern Taiwan: a cross-sectional study based on a trauma registry system.BMC public health · 2016Article
- Adipose tissue-liver axis in alcoholic liver disease.World journal of gastrointestinal pathophysiology · 2016Article
- Biomarker-Based Approaches for Assessing Alcohol Use Disorders.International journal of environmental research and public health · 2016Review
- Interventions for preventing or treating malnutrition in problem drinkers who are homeless or vulnerably housed: protocol for a systematic review.Systematic reviews · 2015Article
- Impacts of common factors of life style on serum liver enzymes.World journal of gastroenterology · 2014Article
- Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease.British journal of pharmacology · 2014Article
- Prevalence of psoriasis among adults in the U.S.: 2003-2006 and 2009-2010 National Health and Nutrition Examination Surveys.American journal of preventive medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this cross-sectional study was to present nationally representative findings on the co-occurrence of obesity and specific patterns of alcohol use associated with elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) among adults in the United States. We analyzed data from 8,373 adults aged ≥ 20 years who participated in the 2005-2008 National Health and Nutrition Examination Survey. We produced prevalence ratios by using the co-occurrence of obesity (i.e., body mass index ≥ 30.0 kg/m(2) or waist circumference ≥ 102 cm in men and ≥ 88 cm in women) and specific patterns of alcohol use (i.e., non-drinkers, non-excessive drinkers, and excessive drinkers) as a predictor; elevations in serum ALT, AST, and GGT were used as an outcome variable while adjusting for covariates in multivariate regression models. Approximately 34.7% of adult men and 38.6% of adult women in the United States had co-occurrence of obesity and any alcohol use, including 16.4% of men and 9.8% of women who had co-occurrence of obesity and excessive drinking during 2005-2008. When compared to male non-drinkers without obesity after multivariate adjustment, male excessive drinkers with obesity were 3.08 (95% CI: 1.80-5.28), 2.42 (95% CI: 1.80-3.26), and 3.15 (95% CI: 1.82-5.46) times more likely to exhibit elevated serum ALT, AST, and GGT, respectively. Similarly, when compared to female non-drinkers without obesity, female excessive drinkers with obesity were 2.36 (95% CI: 1.38-4.04), 3.27 (95% CI: 1.85-5.78), and 3.43 (95% CI: 2.19-5.40) times more likely to have elevated serum ALT, AST, and GGT, respectively. The co-occurrence of obesity and excessive drinking may place adults at an increased risk for potential liver injury. Our study findings provide support for evidence-based clinical and population-based interventions that integrate health behavior change among adults who have these co-occurring risk factors.
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Registered trials
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