ArticleCurrent microbiology2011
Analysis of Escherichia coli isolated from patients affected by Crohn's disease.
Article in Current microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Prevalence, Abundance, and Virulence of Adherent-InvasiveFrontiers in immunology · 2022Article
- Faster and less invasive tools to identify patients with ileal colonization by adherent-invasive E. coli in Crohn's disease.United European gastroenterology journal · 2021Article
- The Role of Enterobacteriaceae in Gut Microbiota Dysbiosis in Inflammatory Bowel Diseases.Microorganisms · 2021Review
- A Novel Strategy to Study the Invasive Capability of Adherent-InvasiveFrontiers in immunology · 2021Article
- The Prevalence of Adherent-InvasiveFrontiers in medicine · 2021Article
- Adherent-InvasiveInternational journal of molecular sciences · 2020Review
- Antimicrobial Resistance Profiles of Adherent InvasiveAntibiotics (Basel, Switzerland) · 2020Article
- Why the discovery of adherent-invasiveWorld journal of biological chemistry · 2020Review
- Article
- Genetic and Phenotypic Features to Screen for Putative Adherent-InvasiveFrontiers in microbiology · 2019Article
- Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease.Medical microbiology and immunology · 2015Article
- Escherichia coli in chronic inflammatory bowel diseases: An update on adherent invasive Escherichia coli pathogenicity.World journal of gastrointestinal pathophysiology · 2014Review
- Understanding host-adherent-invasive Escherichia coli interaction in Crohn's disease: opening up new therapeutic strategies.BioMed research international · 2014Review
- Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiology and molecular biology reviews : MMBR · 2013Review
- Article
- The role of autophagy in Crohn's disease.Cells · 2012Article
- Subversion of autophagy in adherent invasive Escherichia coli-infected neutrophils induces inflammation and cell death.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiopathogenesis of Crohn's disease (CD) is still controversial: several genetic, immunologic, and environmental factors, including some bacteria, have been implicated. This study has been devised to assess the involvement of Escherichia coli in CD. Seven E. coli strains were isolated from 14 biopsies obtained from ileocolic ulcers of patients affected by inflammatory bowel disease (IBD), including six with ulcerative colitis and eight with CD. Five strains, exclusively isolated from CD patients, were found inside mucosal cells. Different PCR techniques (for chuA, yjaA, TspE4.C2, escV, and bfpB genes) were performed and PFGE was carried out to characterize these bacteria in comparison with other E. coli strains isolated from non-IBD specimens. The correlation of these characters with bacterial invasiveness on intestinal (Caco-2) and phagocytic (U937) cells was assessed. Overall our pilot data suggest that five among eight strains isolated from CD patients belonged to the adherent-invasive E. coli (AIEC) group, and were invasive on Caco-2 cells and resistant to phagocytosis. These findings suggest that these bacteria could be considered target organisms whose elimination could reduce the intestinal inflammatory process and CD progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.