ArticleHuman genetics2011
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
Article in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.The pharmacogenomics journal · 2020Pooled it
- Genome-wide meta-analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans.Molecular genetics & genomic medicine · 2019Pooled it
- Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns.Journal of medical genetics · 2019Pooled it
- Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.The pharmacogenomics journal · 2018Pooled it
- Ultrafast genome-wide scan for SNP-SNP interactions in common complex disease.Genome research · 2012Pooled it
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- Congenital heart disease risk loci identified by genome-wide association study in European patients.The Journal of clinical investigation · 2021Trial
- Deep learning identified genetic variants for COVID-19-related mortality among 28,097 affected cases in UK Biobank.Genetic epidemiology · 2023Article
- A genome-wide association study identifies a possible role for cannabinoid signalling in the pathogenesis of diabetic kidney disease.Scientific reports · 2023Article
- Whole exome sequencing reveals genetic landscape associated with left ventricular outflow tract obstruction in Chinese Han population.Frontiers in genetics · 2023Article
- Association of the MACROD2 rs6110695 A>G polymorphism with an increasing WBC count in a Korean population.Immunity, inflammation and disease · 2022Article
- The transcriptional regulator Zfat is essential for maintenance and differentiation of the adipocytes.Journal of cellular biochemistry · 2021Article
- Association of MACROD2 gene variants with obesity and physical activity in a Korean population.Molecular genetics & genomic medicine · 2021Article
- GPR39 localization in the aging human brain and correlation of expression and polymorphism with vascular cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- A Variant in the Nicotinic Acetylcholine Receptor Alpha 3 Subunit Gene Is Associated With Hypertension Risks in Hypogonadic Patients.Frontiers in genetics · 2020Article
- Genome-Wide Association Studies of Hypertension and Several Other Cardiovascular Diseases.Pulse (Basel, Switzerland) · 2019Review
- Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function.Frontiers in physiology · 2019Article
- Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.International journal of molecular medicine · 2018Article
- Genome-wide scan for circulating vascular adhesion protein-1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis.Journal of diabetes investigation · 2018Article
- MatrixEpistasis: ultrafast, exhaustive epistasis scan for quantitative traits with covariate adjustment.Bioinformatics (Oxford, England) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
It has been postulated that multiple-marker methods may have added ability, over single-marker methods, to detect genetic variants associated with disease. The Wellcome Trust Case Control Consortium (WTCCC) provided the first successful large genome-wide association studies (GWAS) which included single-marker association analyses for seven common complex diseases. Of those signals detected, only one was associated with coronary artery disease (CAD), and none were identified for hypertension (HTN). Our objective was to find additional genetic associations and pathways for cardiovascular disease by examining the WTCCC data for variants associated with CAD and HTN using two-marker testing methods. We applied two-marker association testing to the WTCCC dataset, which includes ~2,000 affected individuals with each disorder, and a shared pool of ~3,000 controls, all genotyped using Affymetrix GeneChip 500 K arrays. For CAD, we detected single nucleotide polymorphisms (SNP) pairs in three genes showing genome-wide significance: HFE2, STK32B, and DIPC2. The most notable SNP pairs in a non-protein-coding region were at 9p21, a known major CAD-associated region. For HTN, we detected SNP pairs in five genes: GPR39, XRCC4, MYO6, ZFAT, and MACROD2. Four further associated SNP pair regions were at least 70 kb from any known gene. We have shown that novel, multiple-marker, statistical methods can be of use in finding variants in GWAS. We describe many new, associated variants for both CAD and HTN and describe their known genetic mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.