ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2011
Continuous monitoring of glucose levels in the hepatic vein and systemic circulation during the Pringle maneuver in beagles.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 14 citations in OpenAlex.
- Hepatic clamping and postoperative hyperglycaemia: A retrospective cohort study in liver surgery.European journal of anaesthesiology and intensive care · 2026Article
- Artificial endocrine pancreas with a closed-loop system effectively suppresses the accelerated hyperglycemic status after reperfusion during aortic surgery.General thoracic and cardiovascular surgery · 2021Article
- Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Article
- Comparison of subcutaneous and intravenous continuous glucose monitoring accuracy in an operating room and an intensive care unit.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2016Observational
- Preoperative oral rehydration therapy with 2.5 % carbohydrate beverage alleviates insulin action in volunteers.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2013Article
- Journal of Artificial Organs 2011: the year in review.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2012Review
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8 authors at 2 institutions in 1 country.
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Abstract
Intraoperative continuous glucose monitoring revealed that liver ischemia/reperfusion causes a rapid and profound transition in glucose concentration. We hypothesized that the washout of the glucose stored in the liver leads to a rapid transition in blood glucose concentration. Six female beagles were studied. A portosystemic shunt was established, and the glucose levels in the jugular, hepatic, and portal veins were continuously monitored. All beagles were stabilized for 30 min, and, subsequently, the hepatic artery and portal vein were clamped (the Pringle maneuver). After 30 min of warm hepatic ischemia, the clamp was removed in order to initiate hepatic reperfusion. The endpoint of the experiment was 60 min after the onset of reperfusion. The glucose levels in the abovementioned veins were recorded continuously. The glucose level in the hepatic vein increased 10 min after the start of the Pringle maneuver and was significantly higher than that in the jugular vein and portal vein just before unclamping. The glucose level in the hepatic vein peaked at 2 min after unclamping and that in the portal and jugular veins started to increase after reperfusion. The glucose level in the hepatic vein was significantly higher than that in the jugular and portal veins between 9 min after clamping and 8 min after reperfusion. In conclusion, our study among beagles showed that glucose release from the hepatic vein and sinusoid leads to a rapid elevation in systemic blood glucose levels after liver ischemia/reperfusion. This knowledge might help in the development of new strategies for blood glucose management during hepatectomy.
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