ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.European heart journal · 2022Pooled it
- Quantification of Myocardial Perfusion Reserve Using Dynamic SPECT Imaging in Humans: A Feasibility Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Trial
- Diagnostic and prognostic value of myocardial flow reserve quantification with single photon emission computed tomography - a systematic review and meta-analysis.EJNMMI research · 2025Article
- Comparison of global and regional myocardial blood flow quantification using dynamic solid-state detector SPECT and Tc-99 m-sestamibi or Tc-99 m-tetrofosmin in a routine clinical setting.The international journal of cardiovascular imaging · 2025Article
- Impact on cardiovascular outcome of coronary revascularization-induced changes in ischemic perfusion defect and myocardial flow reserve.European journal of nuclear medicine and molecular imaging · 2024Article
- Estimated Pulse Wave Velocity in the Prediction of Clinical Outcomes in Patients Undergoing Drug-Eluting Stent Implantation.Journal of clinical medicine · 2023Article
- SPECT measurements of myocardial blood flow and flow reserve: from development to implementation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Myocardial perfusion reserve by CZT cameras: A journey inside coronary microvascular circulation. Is it time to leave yet?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of myocardial flow reserve derived by quantitative SPECT for patients with intermediate coronary stenoses.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Myocardial perfusion reserve by using CZT: It's a long way to the top if you wanna standardize.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Sex and gender issues in cardiotoxicity: Are we ready for gynecardiooncology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- First validation of myocardial flow reserve assessed by dynamicEuropean journal of nuclear medicine and molecular imaging · 2018Article
- Prognostic value of atherosclerotic burden and coronary vascular function in patients with suspected coronary artery disease.European journal of nuclear medicine and molecular imaging · 2017Article
- Dynamic SPECT: evolution of a widely available tool for the assessment of coronary flow reserve.European journal of nuclear medicine and molecular imaging · 2015Article
- Survival analysis and regression models.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Review
- 1,25-Dihydroxy vitamin D and coronary microvascular function.European journal of nuclear medicine and molecular imaging · 2013Article
- Prognosis in the era of comparative effectiveness research: where is nuclear cardiology now and where should it be?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Review
- Investigation of dynamic SPECT measurements of the arterial input function in human subjects using simulation, phantom and human studies.Physics in medicine and biology · 2012Article
- Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe assessed the prognostic value of coronary flow reserve (CFR) estimated by single-photon emission computed tomography (SPECT) in patients with suspected myocardial ischemia. METHODS AND
resultsMyocardial perfusion and CFR were assessed in 106 patients using dipyridamole/rest Tc-99m sestamibi SPECT and follow-up was obtained in 103 (97%) patients. Four early revascularized patients were excluded and 99 were assigned to normal (summed stress score <3) vs abnormal myocardial perfusion and to normal (≥2.0) vs abnormal CFR. During the follow-up (5.8 ± 2.1 years), 28 patients experienced a cardiac event (cardiac death, nonfatal myocardial infarction, and late revascularization). Abnormal perfusion (P < .01) and abnormal CFR (P < .05) were independent predictors of cardiac events at Cox proportional hazard regression analysis. Also in patients with normal perfusion, abnormal CFR was associated with a higher annual event rate compared with normal CFR (5.2% vs 0.7%; P < .05). CFR data improved the prognostic power of the model including clinical and myocardial perfusion data increasing the global chi-square from 18.6 to 22.8 (P < .05). Finally, at parametric survival analysis, in patients with normal perfusion the time to achieve ≥2% risk of events was >60 months in those with normal and <12 months in those with abnormal CFR.
conclusionsMyocardial perfusion findings and CFR at SPECT imaging are both independent predictors of cardiac events. Estimated CFR provides incremental prognostic information over those obtained from clinical and myocardial perfusion data, particularly in patients with normal perfusion findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.