ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2012
Expression of staphylococcal superantigens during nasal colonization is not sufficient to induce a systemic neutralizing antibody response in humans.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- The mutational landscape of Staphylococcus aureus during colonisation.Nature communications · 2025Article
- Glucose Mediates Niche-Specific Repression of Staphylococcus aureus Toxic Shock Syndrome Toxin-1 through the Activity of CcpA in the Vaginal Environment.Journal of bacteriology · 2022Article
- Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions.Frontiers in cellular and infection microbiology · 2022Review
- Adaptation ofFrontiers in microbiology · 2021Article
- Allergy-A New Role for T Cell Superantigens ofToxins · 2020Review
- Antineutrophil cytoplasmic antibodies (ANCA) - their role in pathogenesis, diagnosis, and treatment monitoring of ANCA-associated vasculitis.Central-European journal of immunology · 2020Review
- Manipulation of Innate and Adaptive Immunity by Staphylococcal Superantigens.Pathogens (Basel, Switzerland) · 2018Review
- Article
- Omics Approaches for the Study of Adaptive Immunity toProteomes · 2016Review
- Staphylococcal Enterotoxin O Exhibits Cell Cycle Modulating Activity.Frontiers in microbiology · 2016Article
- Prevalence of enterotoxin genes in Staphylococcus aureus colonising food handlers: does nasal carriage status matter?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization.Toxins · 2015Article
- Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design.Frontiers in immunology · 2014Review
- Chronic exposure to staphylococcal superantigen elicits a systemic inflammatory disease mimicking lupus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.Expert opinion on therapeutic targets · 2012Review
- Host- and microbe determinants that may influence the success of S. aureus colonization.Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus carriers have high-titer serum antibodies against non-enterotoxin gene cluster (egc) superantigens, whereas they lack anti-egc antibodies, suggesting different superantigen expression profiles in vivo. We measured the superantigen transcripts in S. aureus directly isolated from the nose of persistent carriers and correlated them with the superantigen-neutralizing antibody response. While neutralizing serum antibodies against the staphylococcal enterotoxins A and C (SEA and SEC) were found in carriers, antibodies against the egc-encoded staphylococcal enterotoxin-like toxin O (SElO) were rare. Surprisingly, the transcription of selo was comparable to sea and sec during nasal colonization. Thus, egc superantigens are transcribed during nasal colonization, but this is not sufficient to induce a serum antibody response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.