ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2011
Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer.BMC cancer · 2019Pooled it
- Human papillomavirus and colorectal cancer.Medical oncology (Northwood, London, England) · 2018Pooled it
- Preliminary exploration of the effects of environmental factors on the microsatellite status of BRAF-mutated colorectal cancer.World journal of surgical oncology · 2023Article
- Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar.Human vaccines & immunotherapeutics · 2023Article
- A comprehensive review on RNA interference-mediated targeting of interleukins and its potential therapeutic implications in colon cancer.3 Biotech · 2023Review
- Molecular Interplay ofArchives of Razi Institute · 2022Article
- Article
- Viruses in colorectal cancer.Molecular oncology · 2022Review
- CpG Island Methylator Phenotype-A Hope for the Future or a Road to Nowhere?International journal of molecular sciences · 2022Review
- Copresence of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon.International journal of molecular sciences · 2021Article
- Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer.Infectious agents and cancer · 2021Review
- Epstein-Barr Virus in the Development of Colorectal Cancer (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Gut eukaryotic virome in colorectal carcinogenesis: Is that a trigger?Computational and structural biotechnology journal · 2021Review
- Co-presence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples.Human vaccines & immunotherapeutics · 2020Article
- Patient-individual cancer cell lines and tissue analysis delivers no evidence of sequences from DNA viruses in colorectal cancer cells.BMC gastroenterology · 2020Article
- High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status.Pathogens (Basel, Switzerland) · 2020Article
- Human Papillomaviruses and Epstein-Barr Virus Interactions in Colorectal Cancer: A Brief Review.Pathogens (Basel, Switzerland) · 2020Review
- Enteric Virome and Carcinogenesis in the Gut.Digestive diseases and sciences · 2020Review
- Article
- Does human papillomavirus cause human colorectal cancer? Applying Bradford Hill criteria postulates.Ecancermedicalscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence that insertion of viral DNA into a mammalian genome can lead to alterations of methylation patterns. The aim of the present study was to examine the presence of DNA sequences of five human DNA viruses (assessed by PCR): JC polyoma virus (JCV), human adenovirus (AdV), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) and human papillomavirus (HPV) in a cohort of 186 sporadic colorectal cancers (CRCs) and related these data with the methylation status of six CpG island methylator phenotype (CIMP)-specific genes (MLH1, CACNA1G, NEUROG1, IGF2, SOCS1, RUNX3) and seven cancer-related genes markers (p16, MINT1, MINT2, MINT31, EN1, SCTR and INHBB) assessed by methylation-specific PCR in 186 and 134 CRC cases, respectively. The AdV, KSHV and HPV were detected in four (2%), two (1%) and zero CRC cases, respectively, and thus were excluded from further analyses. Although 19% and 9% of the CRCs were positive for EBV and JCV, respectively, no associations between virus presence and CpG island methylation were found after correction for multiple testing. Our results demonstrate that the presence of DNA sequences of JCV and EBV in CRC is unrelated to the methylation of the 13 cancer-related CpG islands and CIMP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.