ArticleObesity surgery2011
Reduced cardiovascular risk following bariatric surgeries is related to a partial recovery from "adiposopathy".
Article in Obesity surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis.Obesity surgery · 2019Pooled it
- n3 PUFAs do not affect adipose tissue inflammation in overweight to moderately obese men and women.The Journal of nutrition · 2013Trial
- Differences in Weight Loss Postsleeve Gastrectomy Among Patients With Various Types of Obesity Based on Waist-To-Hip Ratio Classification.Journal of obesity · 2025Article
- Global collaborative research in metabolic and bariatric surgery (GCRMBS): current status and directions for the future.BMC surgery · 2024Review
- Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity.International journal of obesity (2005) · 2022Observational
- Obesity May Not Be Associated with 28-Day Mortality, Duration of Invasive Mechanical Ventilation and Length of Intensive Care Unit and Hospital Stay in Critically Ill Patients with Severe Acute Respiratory Syndrome Coronavirus-2: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2021Observational
- Laparoscopic Roux-En-Y Gastric Bypass Improves Lipid Profile and Decreases Cardiovascular Risk: a 5-Year Longitudinal Cohort Study of 1048 Patients.Obesity surgery · 2018Observational
- Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease.Journal of lipid research · 2017Article
- Does bariatric surgery improve adipose tissue function?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016Review
- The Effects of Bariatric Surgery-Induced Weight Loss on Adipose Tissue in Morbidly Obese Women Depends on the Initial Metabolic Status.Obesity surgery · 2016Article
- Inflammatory "adiposopathy" in major amputation patients.Annals of vascular surgery · 2013Article
- NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.American journal of physiology. Endocrinology and metabolism · 2013Article
- Obesity and inflammation: change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery.Obesity surgery · 2012Article
- Bariatric surgery: effects on the metabolic complications of obesity.Current atherosclerosis reports · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAltered cytokine secretion from dysfunctional adipose tissue or "adiposopathy" is implicated in obesity related inflammation and may mediate reduced cardiovascular disease (CVD) risk in response to weight loss after bariatric surgery. We hypothesized that bariatric surgery reduces CVD risk by favorably altering the pro-inflammatory profile of adipose tissue as a result of weight loss.
methodsIn this observational study with repeated measures, 142 patients underwent bariatric surgery of which 45 returned for follow-up at ∼6 months. At both time-points, lipid profiles and levels of plasma adiponectin, leptin, and TNF-α were obtained. Ratios of various adipokine parameters were related to pre- and post- surgical (gastric bypass vs. other restrictive bariatric procedures) lipid ratios.
resultsPrior to surgery, circulating adiponectin and the adiponectin/TNF-α ratio was strongly associated with CVD risk characterized by levels of triglycerides, HDL, and the TC/HDL, LDL/HDL, and TG/HDL ratios (all P < 0.05). Following bariatric surgery, BMI was decreased by 22%, adiponectin was increased by 93%, and leptin decreased by 50% as compared to baseline (all P < 0.01). TNF-α levels increased by 120% (P < 0.01) following surgery. Post-surgical changes in adiponectin and the leptin/adiponectin ratio were strongly associated with incremental improvements in triglycerides, HDL, and TC/HDL, LDL/HDL and TG/HDL ratios (all P < 0.05). Roux-en-y gastric bypass surgery (RYGB) as compared to other bariatric procedures was associated with more robust improvements in BMI, HDL, and leptin/adiponectin ratio than other gastric restrictive procedures (P < 0.05).
conclusionsThus, bariatric surgery, especially RYGB, ameliorates CVD risk through a partial recovery from "adiposopathy", distinctively characterized by improved adiponectin and the leptin/adiponectin ratio.
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