ArticlePloS one2011
Comparative transcriptome analysis of Bacillus subtilis responding to dissolved oxygen in adenosine fermentation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- New insights into the efficient secretion of foreign protein in Bacillus subtilis via Ribo-seq and RNA-seq integrative analyses.BMC microbiology · 2024Article
- Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization.BMC microbiology · 2023Article
- Comparative transcriptomic and proteomic analysis of Arthrobacter sp. CGMCC 3584 responding to dissolved oxygen for cAMP production.Scientific reports · 2018Article
- Comparative analysis of the Corynebacterium glutamicum transcriptome in response to changes in dissolved oxygen levels.Journal of industrial microbiology & biotechnology · 2017Article
- Significance of oxygen carriers and role of liquid paraffin in improving validamycin A production.Journal of industrial microbiology & biotechnology · 2016Article
- Transcriptional Profiling Analysis of Bacillus subtilis in Response to High Levels of Fe(3.).Current microbiology · 2016Article
- Transcriptome and Multivariable Data Analysis of Corynebacterium glutamicum under Different Dissolved Oxygen Conditions in Bioreactors.PloS one · 2016Article
- A rapid enzymatic assay for high-throughput screening of adenosine-producing strains.Microbial biotechnology · 2015Article
- Article
- Comparative Assessment of Factors Involved in Acetoin Synthesis by Bacillus subtilis 168.ISRN microbiology · 2014Article
- Article
- Time-resolved transcriptomics and bioinformatic analyses reveal intrinsic stress responses during batch culture of Bacillus subtilis.PloS one · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dissolved oxygen (DO) is an important factor for adenosine fermentation. Our previous experiments have shown that low oxygen supply in the growth period was optimal for high adenosine yield. Herein, to better understand the link between oxygen supply and adenosine productivity in B. subtilis (ATCC21616), we sought to systematically explore the effect of DO on genetic regulation and metabolism through transcriptome analysis. The microarrays representing 4,106 genes were used to study temporal transcript profiles of B. subtilis fermentation in response to high oxygen supply (agitation 700 r/min) and low oxygen supply (agitation 450 r/min). The transcriptome data analysis revealed that low oxygen supply has three major effects on metabolism: enhance carbon metabolism (glucose metabolism, pyruvate metabolism and carbon overflow), inhibit degradation of nitrogen sources (glutamate family amino acids and xanthine) and purine synthesis. Inhibition of xanthine degradation was the reason that low oxygen supply enhanced adenosine production. These provide us with potential targets, which can be modified to achieve higher adenosine yield. Expression of genes involved in energy, cell type differentiation, protein synthesis was also influenced by oxygen supply. These results provided new insights into the relationship between oxygen supply and metabolism.
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