ArticlePloS one2011
Receptor sorting within endosomal trafficking pathway is facilitated by dynamic actin filaments.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Impact of 2D versus 3D fibroblast models onFrontiers in cellular and infection microbiology · 2025Article
- WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Role of Akt/Rab5A Signalling in Regulating Cell Migration of MDA-MB-231 Breast Cancer Cell Line.Archives of Razi Institute · 2023Article
- Roles of Endocytic Processes and Early Endosomes on Focal Adhesion Dynamics in MDA-MB-231 Cells.Reports of biochemistry & molecular biology · 2021Article
- Spatially Resolved Correlation between Stiffness Increase and Actin Aggregation around Nanofibers Internalized in Living Macrophages.Materials (Basel, Switzerland) · 2020Article
- Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function.Scientific reports · 2018Article
- Rapid Turnover of the Cardiac L-Type CaiScience · 2018Article
- Retromer Dysfunction and Neurodegenerative Disease.Current genomics · 2018Review
- FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.Scientific reports · 2017Article
- Moesin and cortactin control actin-dependent multivesicular endosome biogenesis.Molecular biology of the cell · 2016Article
- Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization.Scientific reports · 2016Article
- PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes.Molecular biology of the cell · 2016Article
- PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.The Journal of cell biology · 2015Article
- Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells.Current opinion in hematology · 2015Review
- Endosomal Interactions during Root Hair Growth.Frontiers in plant science · 2015Article
- Pannexin2 oligomers localize in the membranes of endosomal vesicles in mammalian cells while Pannexin1 channels traffic to the plasma membrane.Frontiers in cellular neuroscience · 2014Article
- Retromer-mediated endosomal protein sorting: all WASHed up!Trends in cell biology · 2013Review
- Membrane trafficking in podocyte health and disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells.The Journal of experimental medicine · 2013Article
- Arl13b regulates endocytic recycling traffic.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early endosomes (EEs) are known to be a sorting station for internalized molecules destined for degradation, recycling, or other intracellular organelles. Segregation is an essential step in such sorting, but the molecular mechanism of this process remains to be elucidated. Here, we show that actin is required for efficient recycling and endosomal maturation by producing a motile force. Perturbation of actin dynamics by drugs induced a few enlarged EEs containing several degradative vacuoles and also interfered with their transporting ability. Actin repolymerization induced by washout of the drug caused the vacuoles to dissociate and individually translocate toward the perinuclear region. We further elucidated that cortactin, an actin-nucleating factor, was required for transporting contents from within EEs. Actin filaments regulated by cortactin may provide a motile force for efficient sorting within early endosomes. These data suggest that actin filaments coordinate with microtubules to mediate segregation in EEs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.