ArticlePloS one2011
Unexpected course of nonlinear cardiac interbeat interval dynamics during childhood and adolescence.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Characterizing short-term linear and nonlinear heart rate variability in typically developing children and adolescents.Physiological reports · 2026Article
- Determinants of physical activity level in pediatric oncological patients treated with cardiotoxic therapy - a study protocol.BMC pediatrics · 2025Article
- Age-dependent patterns of cardiac complexity unveiled by topological data analysis of pediatric heart rate variability.PloS one · 2025Article
- Heart Rate Asymmetry in Healthy Children.Journal of clinical medicine · 2023Article
- Comprehensive cardiac evaluation to maximal exercise in a contemporary population of prepubertal children.Pediatric research · 2022Article
- Cardiac Evaluation of Exercise Testing in a Contemporary Population of Preschool Children: A New Approach Providing Reference Values.Children (Basel, Switzerland) · 2022Article
- Test-Retest Reliability of Handgrip Strength Measurement in Children and Preadolescents.International journal of environmental research and public health · 2020Article
- Sex- and Age-Dependent Differences in Autonomic Nervous System Functioning in Adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2018Article
- Sleep Instabilities Assessed by Cardiopulmonary Coupling Analysis Increase During Childhood and Adolescence.Frontiers in physiology · 2018Article
- Normative Values for Heart Rate Variability Parameters in School-Aged Children: Simple Approach Considering Differences in Average Heart Rate.Frontiers in physiology · 2018Article
- Detecting abnormality in heart dynamics from multifractal analysis of ECG signals.Scientific reports · 2017Article
- Heart Rate Variability in Healthy Non-Concussed Youth Athletes: Exploring the Effect of Age, Sex, and Concussion-Like Symptoms.Frontiers in neurology · 2017Article
- Measures of Heart Rate Variability in 24-h ECGs Depend on Age but Not Gender of Healthy Children.Frontiers in physiology · 2017Article
- Article
- Interaction Between Heart Rate Variability and Heart Rate in Pediatric Population.Frontiers in physiology · 2015Article
- Article
- Association of cardiovascular risk using non-linear heart rate variability measures with the framingham risk score in a rural population.Frontiers in physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fluctuations of the cardiac interbeat series contain rich information because they reflect variations of other functions on different time scales (e.g., respiration or blood pressure control). Nonlinear measures such as complexity and fractal scaling properties derived from 24 h heart rate dynamics of healthy subjects vary from childhood to old age. In this study, the age-related variations during childhood and adolescence were addressed. In particular, the cardiac interbeat interval series was quantified with respect to complexity and fractal scaling properties. The R-R interval series of 409 healthy children and adolescents (age range: 1 to 22 years, 220 females) was analyzed with respect to complexity (Approximate Entropy, ApEn) and fractal scaling properties on three time scales: long-term (slope β of the power spectrum, log power vs. log frequency, in the frequency range 10(-4) to 10(-2) Hz) intermediate-term (DFA, detrended fluctuation analysis, α(2)) and short-term (DFA α(1)). Unexpectedly, during age 7 to 13 years β and ApEn were higher compared to the age <7 years and age >13 years (β: -1.06 vs. -1.21; ApEn: 0.88 vs. 0.74). Hence, the heart rate dynamics were closer to a 1/f power law and most complex between 7 and 13 years. However, DFA α(1) and α(2) increased with progressing age similar to measures reflecting linear properties. In conclusion, the course of long-term fractal scaling properties and complexity of heart rate dynamics during childhood and adolescence indicates that these measures reflect complex changes possibly linked to hormonal changes during pre-puberty and puberty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.