ArticlePloS one2011
Mechanism of estradiol-induced block of voltage-gated K+ currents in rat medial preoptic neurons.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Physiological 17β-oestradiol inhibits KChannels (Austin, Tex.) · 2026Article
- Cholesterol and Cholesterol-Derived Molecules Differentially Modulate Neuronal Kv7.2/7.3 Channels.Archiv der Pharmazie · 2026Article
- Inhibitory effect of 17β-estradiol on the THIK-1 channel.PloS one · 2026Article
- Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1.Science advances · 2023Article
- Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice.American journal of physiology. Heart and circulatory physiology · 2022Article
- The modulation of potassium channels by estrogens facilitates neuroprotection.Frontiers in cell and developmental biology · 2022Review
- Role of estrogen and stress on the brain-gut axis.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Plasticity of paternity: Effects of fatherhood on synaptic, intrinsic and morphological characteristics of neurons in the medial preoptic area of male California mice.Behavioural brain research · 2019Article
- The mysteries of menopause and urogynecologic health: clinical and scientific gaps.Menopause (New York, N.Y.) · 2019Review
- Inhibition of blood-brain barrier efflux transporters promotes seizure in pregnant rats: Role of circulating factors.Brain, behavior, and immunity · 2018Article
- Cooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity.Molecular neurobiology · 2017Review
- Nongenomic modulation of the large conductance voltage- and CaPhysiological reports · 2017Article
- Myometrial relaxation of mice via expression of two pore domain acid sensitive K(+) (TASK-2) channels.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Review
- How to Properly Measure a Current-Voltage Relation?-Interpolation vs. Ramp Methods Applied to Studies of GABAA Receptors.Frontiers in cellular neuroscience · 2016Article
- Autoimmune Disease pH and Temperature.Journal of clinical medicine research · 2014Article
- 17β-estradiol downregulated the expression of TASK-1 channels in mouse neuroblastoma N2A cells.The Journal of membrane biology · 2014Article
- Firing clamp: a novel method for single-trial estimation of excitatory and inhibitory synaptic neuronal conductances.Frontiers in cellular neuroscience · 2014Article
- 17β-Estradiol inhibits outward voltage-gated K⁺ currents in human osteoblast-like MG63 cells.The Journal of membrane biology · 2013Article
- Small-molecule hormones: molecular mechanisms of action.International journal of endocrinology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was conducted to characterize possible rapid effects of 17-β-estradiol on voltage-gated K(+) channels in preoptic neurons and, in particular, to identify the mechanisms by which 17-β-estradiol affects the K(+) channels. Whole-cell currents from dissociated rat preoptic neurons were studied by perforated-patch recording. 17-β-Estradiol rapidly (within seconds) and reversibly reduced the K(+) currents, showing an EC(50) value of 9.7 µM. The effect was slightly voltage dependent, but independent of external Ca(2+), and not sensitive to an estrogen-receptor blocker. Although 17-α-estradiol also significantly reduced the K(+) currents, membrane-impermeant forms of estradiol did not reduce the K(+) currents and other estrogens, testosterone and cholesterol were considerably less effective. The reduction induced by estradiol was overlapping with that of the K(V)-2-channel blocker r-stromatoxin-1. The time course of K(+) current in 17-β-estradiol, with a time-dependent inhibition and a slight dependence on external K(+), suggested an open-channel block mechanism. The properties of block were predicted from a computational model where 17-β-estradiol binds to open K(+) channels. It was concluded that 17-β-estradiol rapidly reduces voltage-gated K(+) currents in a way consistent with an open-channel block mechanism. This suggests a new mechanism for steroid action on ion channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.