ArticleProstate cancer and prostatic diseases2011
Inhibitory member of the apoptosis-stimulating protein of p53 (ASPP) family promotes growth and tumorigenesis in human p53-deficient prostate cancer cells.
Article in Prostate cancer and prostatic diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.Structure (London, England : 1993) · 2019Article
- iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer.Cell death & disease · 2017Article
- CDK1 interacts with iASPP to regulate colorectal cancer cell proliferation through p53 pathway.Oncotarget · 2017Article
- iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatinOncotarget · 2017Article
- Total triterpenoids from Ganoderma Lucidum suppresses prostate cancer cell growth by inducing growth arrest and apoptosis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumors.Oncotarget · 2015Review
- Downregulation of inhibitor of apoptosis‑stimulating protein of p53 inhibits proliferation and promotes apoptosis of gastric cancer cells.Molecular medicine reports · 2015Article
- Nuclear iASPP may facilitate prostate cancer progression.Cell death & disease · 2014Article
- In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Article
- MicroRNA124 regulate cell growth of prostate cancer cells by targeting iASPP.International journal of clinical and experimental pathology · 2014Article
- Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is required for neuronal survival after axonal injury.PloS one · 2014Article
- MicroRNA-124 regulates the proliferation of colorectal cancer cells by targeting iASPP.BioMed research international · 2013Article
- Elevated expression of iASPP in head and neck squamous cell carcinoma and its clinical significance.Medical oncology (Northwood, London, England) · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
iASPP is a member of the apoptosis-stimulating protein of p53 (ASPP) family and an evolutionarily conserved inhibitor of p53. Higher levels of iASPP proteins were examined in paraffin-embedded sections collected from 30 patients with prostate cancer using an immunohistochemical method. We found that specially knocking down iASPP with lentivirus-mediated small interfering RNA inhibited the growth, in vitro colony-forming capacity and in vivo tumorigenesis of p53-defective prostate cancer cells. Importantly, inhibition of iASPP induced cell apoptosis, which confers the inhibitory effect on cell survival. We conclude that iASPP is essential for prostate cancer cellular proliferation and survival and may be a potential target for the gene therapy for prostate cancer.
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