ReviewMolecular psychiatry2012
Deep brain stimulation and the role of astrocytes.
Review in Molecular psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 124 citations in OpenAlex.
- A randomized double-blind crossover trial of deep brain stimulation of the subcallosal cingulate gyrus in patients with treatment-resistant depression: a pilot study of relapse prevention.Journal of psychiatry & neuroscience : JPN · 2015Trial
- Early responses to deep brain stimulation in depression are modulated by anti-inflammatory drugs.Molecular psychiatry · 2014Trial
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- Temporal Interference Stimulation Enhances Neural Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Screening for compounds released from deep brain stimulation probes by contact with a brain simulant.Scientific reports · 2026Article
- Frequency- and Layer-Specific Modulation of Cortical Neuronal Activity by Pulsed Electrical Stimulation.MedComm · 2026Article
- Characteristics of resting-state EEG after deep brain stimulation in nucleus accumbens and anterior limb of internal capsule: a pilot study.BMC psychiatry · 2026Article
- STN-DBS exerts neuroprotection and anti-inflammatory effects in a Parkinson's disease rat model.Frontiers in immunology · 2026Article
- Electrical Stimulation of Cells: Drivers, Technology, and Effects.Chemical reviews · 2025Review
- Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Insertional effect following electrode implantation: an underreported but important phenomenon.Brain communications · 2024Review
- Cellular and Molecular Mechanisms and Innovative Neurostimulation Treatments in the Management of Traumatic Brain Injury.Journal of biotechnology and biomedicine · 2024Article
- Do astrocytes respond to light, sound, or electrical stimulation?Neural regeneration research · 2023Article
- Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors.CNS neuroscience & therapeutics · 2023Article
- Insular cortex stimulation alleviates neuropathic pain via ERK phosphorylation in neurons.CNS neuroscience & therapeutics · 2023Article
- Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms.Aging and disease · 2023Article
- Analysis of the influences of social isolation on cognition and the therapeutic potential of deep brain stimulation in a mouse model.Frontiers in psychiatry · 2023Article
- The effects of electrical stimulation on glial cell behaviour.BMC biomedical engineering · 2022Review
- Engineering Tissues of the Central Nervous System: Interfacing Conductive Biomaterials with Neural Stem/Progenitor Cells.Advanced healthcare materials · 2022Review
- The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease.Frontiers in neuroscience · 2022Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) has emerged as a powerful surgical therapy for the management of treatment-resistant movement disorders, epilepsy and neuropsychiatric disorders. Although DBS may be clinically effective in many cases, its mode of action is still elusive. It is unclear which neural cell types are involved in the mechanism of DBS, and how high-frequency stimulation of these cells may lead to alleviation of the clinical symptoms. Neurons have commonly been a main focus in the many theories explaining the working mechanism of DBS. Recent data, however, demonstrates that astrocytes may be active players in the DBS mechanism of action. In this review article, we will discuss the potential role of reactive and neurogenic astrocytes (neural progenitors) in DBS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.