ReviewJournal of musculoskeletal & neuronal interactions2011
Tendon fatigue in response to mechanical loading.
Review in Journal of musculoskeletal & neuronal interactions, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Effects of Mechanical Loading on the Structure and Function of the Achilles Tendon: From Homeostatic Adaptation to Pathological Degeneration.Journal of functional morphology and kinesiology · 2026Review
- Distal triceps tendon rupture repair results in high return to sport rates for amateur and professional athletes: a systematic review.JSES reviews, reports, and techniques · 2026Article
- Collagen Mechanics.Sub-cellular biochemistry · 2026Review
- Shear wave propagation as a noninvasive metric of loading and microdamage in tendon fascicles.Journal of the mechanical behavior of biomedical materials · 2025Article
- Molecular Biology of ACL Graft Healing: Early Mechanical Loading Perspective.Orthopedic reviews · 2025Article
- Repetitive Overuse Injury Causes Entheseal Damage and Palmar Muscle Fibrosis in Older Rats.International journal of molecular sciences · 2024Article
- Successive tendon injury in anFrontiers in bioengineering and biotechnology · 2024Article
- A comparison of individual force decline profiles during a fatiguing eccentric trunk flexion and extension protocol: a pilot study.Frontiers in sports and active living · 2024Article
- Murine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.Journal of visualized experiments : JoVE · 2023Article
- A passive ankle dorsiflexion testing system to assess mechanobiological and structural response to cyclic loading in rat Achilles tendon.Journal of biomechanics · 2023Article
- Identification of runner fatigue stages based on inertial sensors and deep learning.Frontiers in bioengineering and biotechnology · 2023Article
- The impaired healing hypothesis: a mechanism by which psychosocial stress and personal characteristics increase MSD risk?Ergonomics · 2022Article
- Pelvic floor muscle injury during a difficult labor. Can tissue fatigue damage play a role?International urogynecology journal · 2022Article
- Tendinopathy and tendon material response to load: What we can learn from small animal studies.Acta biomaterialia · 2021Review
- Training Load and Injury: Causal Pathways and Future Directions.Sports medicine (Auckland, N.Z.) · 2021Review
- High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells.Stem cell research & therapy · 2020Article
- Analysis of the effect of overusing thumbs on smartphone games.The Journal of international medical research · 2019Article
- How do tendons adapt? Going beyond tissue responses to understand positive adaptation and pathology development: A narrative review.Journal of musculoskeletal & neuronal interactions · 2019Review
- Multiscale model of fatigue of collagen gels.Biomechanics and modeling in mechanobiology · 2019Article
- Promoting effective tendon healing and remodeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tendinopathies are commonly attributable to accumulation of sub-rupture fatigue damage from repetitive use. Data is limited to late stage disease from patients undergoing surgery, motivating development of animal models, such as ones utilizing treadmill running or repetitive reaching, to investigate the progression of tendinopathies. We developed an in vivo model using the rat patellar tendon that allows control of the loading directly applied to the tendon. This manuscript discusses the response of tendons to fatigue loading and applications of our model. Briefly, the fatigue life of the tendon was used to define low, moderate and high levels of fatigue loading. Morphological assessment showed a progression from mild kinks to fiber disruption, for low to high level fatigue loading. Collagen expression, 1 and 3 days post loading, showed more modest changes for low and moderate than high level fatigue loading. Protein and mRNA expression of Ineterleukin-1β and MMP-13 were upregulated for moderate but not low level fatigue loading. Moderate level (7200 cycles) and 100 cycles of fatigue loading resulted in a catabolic and anabolic molecular profile respectively, at both 1 and 7 days post loading. Results suggest unique mechanisms for different levels of fatigue loading that are distinct from laceration.
Indexed as
Identifiers
21625047PMC4408766W2342227228What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.