ArticleGenetics2011
Genetic draft and quasi-neutrality in large facultatively sexual populations.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 92 citations in OpenAlex.
- Evolutionary dynamics under phenotypic uncertainty.bioRxiv : the preprint server for biology · 2026Article
- Evolution of evolvability in rapidly adapting populations.Nature ecology & evolution · 2024Article
- Detecting bacterial adaptation within individual microbiomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- TreeKnit: Inferring ancestral reassortment graphs of influenza viruses.PLoS computational biology · 2022Article
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- Evolution of resistance under alternative models of selective interference.Journal of evolutionary biology · 2021Article
- Limited Predictability of Amino Acid Substitutions in Seasonal Influenza Viruses.Molecular biology and evolution · 2021Article
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- Pervasive Linked Selection and Intermediate-Frequency Alleles Are Implicated in an Evolve-and-Resequencing Experiment ofGenetics · 2019Article
- Effective models and the search for quantitative principles in microbial evolution.Current opinion in microbiology · 2018Review
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- Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys.Communications biology · 2018Article
- Background selection as null hypothesis in population genomics: insights and challenges fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Deep sequencing of natural and experimental populations ofGenome research · 2017Article
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- The evolutionarily stable distribution of fitness effects.Genetics · 2015Article
- Thermal stabilization of dihydrofolate reductase using monte carlo unfolding simulations and its functional consequences.PLoS computational biology · 2015Article
- Cryptic genetic variation can make "irreducible complexity" a common mode of adaptation in sexual populations.Evolution; international journal of organic evolution · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Large populations may contain numerous simultaneously segregating polymorphisms subject to natural selection. Since selection acts on individuals whose fitness depends on many loci, different loci affect each other's dynamics. This leads to stochastic fluctuations of allele frequencies above and beyond genetic drift-an effect known as genetic draft. Since recombination disrupts associations between alleles, draft is strong when recombination is rare. Here, we study a facultatively outcrossing population in a regime where the frequency of outcrossing and recombination, r, is small compared to the characteristic scale of fitness differences σ. In this regime, fit genotypes expand clonally, leading to large fluctuations in the number of recombinant offspring genotypes. The power law tail in the distribution of the latter makes it impossible to capture the dynamics of draft by an effective neutral model. Instead, we find that the fixation time of a neutral allele increases only slowly with the population size but depends sensitively on the ratio r/σ. The efficacy of selection is reduced dramatically and alleles behave "quasi-neutrally" even for Ns≫1, provided that |s| < s(c), where s(c) depends strongly on r/σ, but only weakly on population size N. In addition, the anomalous fluctuations due to draft change the spectrum of (quasi)-neutral alleles from f(ν) ∼ ν(-1), corresponding to drift, to ∼ ν(-2). Finally, draft accelerates the rate of two-step adaptations through deleterious intermediates.
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