ArticleThe Journal of physiology2011
The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 77 citations in OpenAlex.
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- Functional transition of CA2 pyramidal neurons along the proximodistal axis determines resonance frequency preference.Scientific reports · 2026Article
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- Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Understanding Primary Blast Injury: High Frequency Pressure Acutely Disrupts Neuronal Network Dynamics in Cerebral Organoids.Journal of neurotrauma · 2022Article
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences.Nature communications · 2021Article
- Developmentally Regulated Rebound Depolarization Enhances Spike Timing Precision in Auditory Midbrain Neurons.Frontiers in cellular neuroscience · 2020Article
- Active membrane conductances and morphology of a collision detection neuron broaden its impedance profile and improve discrimination of input synchrony.Journal of neurophysiology · 2019Article
- Frequency-dependent responses of neuronal models to oscillatory inputs in current versus voltage clamp.Biological cybernetics · 2019Article
- Membrane potential resonance in non-oscillatory neurons interacts with synaptic connectivity to produce network oscillations.Journal of computational neuroscience · 2019Article
- Dynamical Mechanism of Hyperpolarization-Activated Non-specific Cation Current Induced Resonance and Spike-Timing Precision in a Neuronal Model.Frontiers in cellular neuroscience · 2018Article
- Non-Decaying postsynaptics potentials and delayed spikes in hippocampal pyramidal neurons generated by a zero slope conductance created by the persistent NaChannels (Austin, Tex.) · 2018Article
- Spiking resonances in models with the same slow resonant and fast amplifying currents but different subthreshold dynamic properties.Journal of computational neuroscience · 2017Article
- Plasticity of intrinsic excitability during LTD is mediated by bidirectional changes in h-channel activity.Scientific reports · 2017Article
- Resonance modulation, annihilation and generation of anti-resonance and anti-phasonance in 3D neuronal systems: interplay of resonant and amplifying currents with slow dynamics.Journal of computational neuroscience · 2017Article
- Dopamine Neurons Change the Type of Excitability in Response to Stimuli.PLoS computational biology · 2016Article
- Membrane potential resonance frequency directly influences network frequency through electrical coupling.Journal of neurophysiology · 2016Article
- High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperpolarization-activated cyclic nucleotide modulated current (I(h)) sets resonance frequency within the θ-range (5–12 Hz) in pyramidal neurons. However, its precise contribution to the temporal fidelity of spike generation in response to stimulation of excitatory or inhibitory synapses remains unclear. In conditions where pharmacological blockade of I(h) does not affect synaptic transmission, we show that postsynaptic h-channels improve spike time precision in CA1 pyramidal neurons through two main mechanisms. I(h) enhances precision of excitatory postsynaptic potential (EPSP)--spike coupling because I(h) reduces peak EPSP duration. I(h) improves the precision of rebound spiking following inhibitory postsynaptic potentials (IPSPs) in CA1 pyramidal neurons and sets pacemaker activity in stratum oriens interneurons because I(h) accelerates the decay of both IPSPs and after-hyperpolarizing potentials (AHPs). The contribution of h-channels to intrinsic resonance and EPSP waveform was comparatively much smaller in CA3 pyramidal neurons. Our results indicate that the elementary mechanisms by which postsynaptic h-channels control fidelity of spike timing at the scale of individual neurons may account for the decreased theta-activity observed in hippocampal and neocortical networks when h-channel activity is pharmacologically reduced.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.