ArticleMolecular and cellular biology1990
Down regulation by p60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cells.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Distinct roles for N-Cadherin linked c-Src and fyn kinases in lens development.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Notch signaling activation suppresses v-Src-induced transformation of neural cells by restoring TGF-β-mediated differentiation.PloS one · 2010Article
- Stable expression of intracellular Notch suppresses v-Src-induced transformation in avian neural cells.Oncogene · 2007Article
- Phosphorylation of MafA is essential for its transcriptional and biological properties.Molecular and cellular biology · 2001Article
- Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways.Molecular and cellular biology · 2000Article
- Characterization of a novel quiescence responsive element downregulated by v-Src in the promoter of the neuroretina specific QR1 gene.Oncogene · 2000Article
- Inhibition of src family kinases by a combinatorial action of 5'-AMP and small heat shock proteins, identified from the adult heart.Molecular and cellular biology · 1999Article
- Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein.Molecular and cellular biology · 1995Article
- A Bcl-2-related gene is activated in avian cells transformed by the Rous sarcoma virus.The EMBO journal · 1995Article
- Developmental control of transcription of a retina-specific gene, QR1, during differentiation: involvement of factors from the POU family.Molecular and cellular biology · 1995Article
- Transcriptional downregulation of the retina-specific QR1 gene by pp60v-src and identification of a novel v-src-responsive unit.Molecular and cellular biology · 1993Article
- V-src-induced-transcription of the avian clusterin gene.Nucleic acids research · 1992Article
- Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells.Journal of virology · 1992Article
- Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development.Molecular and cellular biology · 1992Article
- Transcription of muscle-specific genes is repressed by reactivation of pp60v-src in postmitotic quail myotubes.Molecular and cellular biology · 1991Article
- Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The avian neuroretina (NR) is composed of photoreceptors and different neurons that are derived from proliferating precursor cells. Neuronal differentiation takes place after terminal mitosis. We have previously shown that differentiating NR cells can be induced to proliferate by infection with Rous sarcoma virus (RSV) and that cell multiplication requires expression of a functional v-src gene. We speculated that the quiescence of NR cells could be determined by specific genes. Cell proliferation could then result from the negative regulation of these genes by the v-src protein. By differential hybridization of a cDNA library, we isolated eight clones corresponding to genes expressed in postmitotic NR cells from 13-day-old quail embryos, transcriptional levels of which are significantly reduced in NR cells induced to proliferate by tsNY68, an RSV mutant with temperature-sensitive mitogenic activity. Partial sequencing analysis indicated that one RNA encoded the calmodulin gene, whereas the other seven showed no similarity to known sequences. By using v-src mutants that induce NR cell proliferation in the absence of transformation, we showed that transcription of six genes was negatively regulated by the v-src protein and that of four genes was correlated with NR cell quiescence. We also report that a subset of genes are specifically transcribed in neural cells and developmentally regulated in the NR. These results indicate that the v-src protein regulates expression of genes likely to play a role in the control of neural cell growth or differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.