ArticleUrology2011
Functional, metabolic, and morphologic characteristics of a novel rat model of type 2 diabetes-associated erectile dysfunction.
Article in Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Upregulation in Inflammation and Collagen Expression in Perirenal but Not in Mesenteric Adipose Tissue from Diabetic Munich Wistar Frömter Rats.International journal of molecular sciences · 2023Article
- Article
- In vitro high glucose increases apoptosis, decreases nerve outgrowth, and promotes survival of sympathetic pelvic neurons.Sexual medicine · 2023Article
- Urine-Derived Stem Cells Versus Their Lysate in Ameliorating Erectile Dysfunction in a Rat Model of Type 2 Diabetes.Frontiers in physiology · 2022Article
- Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries.Frontiers in pharmacology · 2020Article
- Gross saponin ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Downregulation of lncRNA MALAT1 contributes to renal functional improvement after duodenal-jejunal bypass in a diabetic rat model.Journal of physiology and biochemistry · 2018Article
- Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications.Scientific reports · 2018Article
- Effects of Next-Generation Low-Energy Extracorporeal Shockwave Therapy on Erectile Dysfunction in an Animal Model of Diabetes.The world journal of men's health · 2017Article
- CMD-05, a novel promising clinical anti-diabetic drug candidate, in vivo and vitro studies.Scientific reports · 2017Article
- Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic men with erectile dysfunction.Andrology · 2017Article
- Article
- Mechanistic link between erectile dysfunction and systemic endothelial dysfunction in type 2 diabetic rats.Andrology · 2016Article
- Translational Perspective on the Role of Testosterone in Sexual Function and Dysfunction.The journal of sexual medicine · 2016Review
- High-fat diet combined with low-dose streptozotocin injections induces metabolic syndrome in Macaca mulatta.Endocrine · 2015Article
- Effects of Icariside II on corpus cavernosum and major pelvic ganglion neuropathy in streptozotocin-induced diabetic rats.International journal of molecular sciences · 2014Article
- Modeling type 2 diabetes in rats using high fat diet and streptozotocin.Journal of diabetes investigation · 2014Review
- Human urine-derived stem cells alone or genetically-modified with FGF2 Improve type 2 diabetic erectile dysfunction in a rat model.PloS one · 2014Article
- Direct androgen regulation of PDE5 gene or the lack thereof.International journal of impotence research · 2013Review
- Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model.The journal of sexual medicine · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesTo conduct a pilot study to investigate functional, metabolic, and penile morphologic changes in a novel model of lean DM2. Erectile dysfunction (ED) is a frequent sequela in patients with type 2 diabetes mellitus (DM2).
methodsEight rats received a high-fat diet and 2 weeks later, 2 intraperitoneal injections of streptozotocin (STZ, 30 mg/kg). Five age-matched rats served as controls. Insulin challenge tests were performed at 6 and 12 weeks after induction of DM2. At 12 weeks, erectile function was tested by measurement of intracavernous pressure (ICP) increase upon cavernous nerve stimulation. Penile tissue and serum samples were harvested for histology and biochemistry, respectively.
resultsA lean DM2 model was established as demonstrated by decreased insulin resistance, elevated nonfasting plasma glucose levels, hyperlipidemia, and decreased insulin concentration in the absence of obesity. ICP/mean arterial pressure was significantly decreased in DM2 animals (0.29) compared with controls (0.81). Expression of neuronal nitric oxide synthase and rat endothelial cell antigen-1, and the smooth muscle/collagen ratio were significantly decreased in the penis of DM2 animals.
conclusionsWe propose an inexpensive nongenetic animal model of lean DM2-associated ED. Microanatomical changes in the erectile tissue that reflect an advanced stage of the disease were observed.
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