Evidence map›Paper›PMID 21624561›Full record

ReviewSeminars in nuclear medicine2011

The next generation of positron emission tomography radiopharmaceuticals in oncology.

Samuel L Rice, Celeste A Roney, Pierre Daumar, Jason S Lewis

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in nuclear medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. The diagnostic performance ofBMC medical imaging · 2017
    Pooled it
  2. Article
  3. Cold Kit Labeling: The Future ofFrontiers in medicine · 2022
    Review
  4. PET Imaging of the Natural Killer Cell Activation Receptor NKp30.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  5. IntratumoralEJNMMI research · 2019
    Article
  6. Bioconjugate chemistry · 2018
    Review
  7. Prospective ofContrast media & molecular imaging · 2018
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2015
    Article
  15. A nuclear chocolate box: the periodic table of nuclear medicine.Dalton transactions (Cambridge, England : 2003) · 2015
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Samuel L RiceRadiochemistry Service, Department of Radiology and Program in Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, USA.
Celeste A Roney
Pierre Daumar
Jason S Lewis
Memorial Sloan Kettering Cancer Center · US

Funding

Molecular Imaging: Training for OncologyR25CA096945 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HRICAK, HEDVIG · 2002 to 2013
$5.2M
Biomarkers for predicting response to Hsp90 therapyR01CA172546 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, DUNPHY, MARK P. · 2013 to 2017
$2.9M
NCI NIH HHS R01 CA172546NCI NIH HHS R25 CA096945NCI NIH HHS R25T CA046945
6 · The paper itself

Abstract

Although (18)F-fluorodeoxyglucose ((18)F-FDG) is still the most widely used positron emission tomography (PET) radiotracer, there are a few well-known limitations to its use. The last decade has seen the development of new PET probes for in vivo visualization of specific molecular targets, along with important technical advances in the production of positron-emitting radionuclides and their related labeling methods. As such, a broad range of new PET tracers are in preclinical development or have recently entered clinical trials. The topics covered in this review include labeling methods, biological targets, and the most recent preclinical or clinical data of some of the next generation of PET radiopharmaceuticals. This review, which is by no means exhaustive, has been separated into sections related to the PET radionuclide used for radiolabeling: fluorine-18, for the labeling of agents such as FACBC, FDHT, choline, and Galacto-RGD; carbon-11, for the labeling of choline; gallium-68, for the labeling of peptides such as DOTATOC and bombesin analogs; and the long-lived radionuclides iodine-124 and zirconium-89 for the labeling of monoclonal antibodies cG250, and J591 and trastuzumab, respectively.

Indexed as

Antibodies, MonoclonalCarbon RadioisotopesFluorine RadioisotopesGallium RadioisotopesIodine RadioisotopesIsotope LabelingMedical OncologyPositron-Emission TomographyRadioisotopesRadiopharmaceuticalsZirconiumAntibodies, MonoclonalCarbon RadioisotopesFluorine RadioisotopesGallium RadioisotopesIodine RadioisotopesRadioisotopesRadiopharmaceuticalsZirconium

Identifiers

PMID21624561
PMCPMC4406404
OpenAlexW2020098043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.